DDR2 Antikörper (AA 290-320)

Produktnummer ABIN3030740

Produktdetails anti-DDR2 Antikörper

Target: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Bindungsspezifität: AA 290-320

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Purified

Immunogen: A portion of amino acids 290-320 from the human protein was used as the immunogen for this DDR2 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the DDR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the DDR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu DDR2

Target: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Andere Bezeichnung: DDR2 (DDR2 Produkte)

Synonyme: MIG20a antikoerper, NTRKR3 antikoerper, TKT antikoerper, TYRO10 antikoerper, AW495251 antikoerper, Ntrkr3 antikoerper, tyro10 antikoerper, DDR2 antikoerper, Tyro10 antikoerper, ddr2 antikoerper, si:ch211-193c2.1 antikoerper, discoidin domain receptor tyrosine kinase 2 antikoerper, discoidin domain receptor family, member 2 antikoerper, discoidin domain receptor family, member 2, like antikoerper, DDR2 antikoerper, Ddr2 antikoerper, ddr2l antikoerper

Hintergrund: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane and cytoplasmic regions. There are several subclasses of RTKs and TYRO10 belongs to a novel subclass. The deduced amino acid sequence of TYRO10 has a unique extracellular region encompassing a factor VIII-like domain, not previously described for RTKs.

UniProt: Q16832

Pathways: RTK Signalweg