CD46 Antikörper (AA 330-361)

Produktnummer ABIN3030406

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CD46 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CD46 Antikörper (AA 330-361) (ABIN3030406)

Target: CD46

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD46 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CD46 Antikörper

Bindungsspezifität: AA 330-361

Aufreinigung: Antigen affinity purified

Immunogen: A portion of amino acids 330-361 from the human protein was used as the immunogen for this CD46 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the CD46 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the CD46 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu CD46

Target: CD46

Andere Bezeichnung: CD46

Hintergrund: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization