CD46 Antikörper (CD46)

Produktnummer ABIN125715

Produktdetails anti-CD46 Antikörper

Target: CD46

Reaktivität: Human, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD46 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)

Spezifität: The antibody MEM-258 recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast, it is negative on erythrocytes.

Kreuzreaktivität (Details): Human, Bovine

Aufreinigung: Purified by protein-A affinity chromatography

Reinheit: > 95 % (by SDS-PAGE)

Sterilität: 0.2 μm filtered

Immunogen: HPB-ALL human T cell line

Klon: MEM-258

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μ,m filter sterilized.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.

Referenzen für anti-CD46 Antikörper (ABIN125715)

Kälin, Amstutz, Gastaldelli, Wolfrum, Boucke, Havenga, DiGennaro, Liska, Hemmi, Greber: "Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35." in: Journal of virology, Vol. 84, Issue 10, pp. 5336-50, (2010) (PubMed).

Wang, Tuve, Erdman, Lieber: "Receptor usage of a newly emergent adenovirus type 14." in: Virology, Vol. 387, Issue 2, pp. 436-41, (2009) (PubMed).

Hoffmann, Bayer, Heim, Potthoff, Nettelbeck, Wildner: "Evaluation of twenty-one human adenovirus types and one infectivity-enhanced adenovirus for the treatment of malignant melanoma." in: The Journal of investigative dermatology, Vol. 128, Issue 4, pp. 988-98, (2008) (PubMed).

Fleischli, Sirena, Lesage, Havenga, Cattaneo, Greber, Hemmi: "Species B adenovirus serotypes 3, 7, 11 and 35 share similar binding sites on the membrane cofactor protein CD46 receptor." in: The Journal of general virology, Vol. 88, Issue Pt 11, pp. 2925-34, (2007) (PubMed).

Weyand, Lee, Higashi, Cawley, Yoshihara, So: "Monoclonal antibody detection of CD46 clustering beneath Neisseria gonorrhoeae microcolonies." in: Infection and immunity, Vol. 74, Issue 4, pp. 2428-35, (2006) (PubMed).

Fremeaux-Bacchi, Moulton, Kavanagh, Dragon-Durey, Blouin, Caudy, Arzouk, Cleper, Francois, Guest, Pourrat, Seligman, Fridman, Loirat, Atkinson: "Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome." in: Journal of the American Society of Nephrology : JASN, Vol. 17, Issue 7, pp. 2017-25, (2006) (PubMed).

Fleischli, Verhaagh, Havenga, Sirena, Schaffner, Cattaneo, Greber, Hemmi: "The distal short consensus repeats 1 and 2 of the membrane cofactor protein CD46 and their distance from the cell membrane determine productive entry of species B adenovirus serotype 35." in: Journal of virology, Vol. 79, Issue 15, pp. 10013-22, (2005) (PubMed).

Details zu CD46

Target: CD46

Andere Bezeichnung: CD46 (CD46 Produkte)

Synonyme: AHUS2, MCP, MIC10, TLX, TRA2.10, Mcp, CD46, CD46 molecule, CD46 antigen, complement regulatory protein, CD46 molecule, complement regulatory protein, membrane cofactor protein-like, CD46, Cd46, LOC100341359, LOC103789310

Hintergrund: CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.

Pathways: Regulation of Actin Filament Polymerization