APC Antikörper (AA 1148-1176)

Produktnummer ABIN3029869

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch APC in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für APC Antikörper (AA 1148-1176) (ABIN3029869)

Target: APC (Adenomatous Polyposis Coli (APC))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-APC Antikörper

Bindungsspezifität: AA 1148-1176

Verwendungszweck: APC Antibody / Adenomatous polyposis coli

Aufreinigung: Antigen affinity

Immunogen: A portion of amino acids 1148-1176 from the human protein was used as the immunogen for this APC antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the APC antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the APC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu APC

Target: APC (Adenomatous Polyposis Coli (APC))

Andere Bezeichnung: APC

Hintergrund: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

UniProt: P25054

Pathways: WNT Signalweg, Stem Cell Maintenance, Cell-Cell Junction Organization