PKM2 Antikörper

Produktnummer ABIN4953284

Dieses Anti-PKM2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von PKM2 in WB, IF und ICC. Geeignet für Human, Maus, Ratte und Primate.

Kurzübersicht für PKM2 Antikörper (ABIN4953284)

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Reaktivität: Human, Maus, Ratte, Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PKM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: 1A7-G6-H6

Produktdetails anti-PKM2 Antikörper

Aufreinigung: Protein G affinity

Immunogen: A human recombinant partial protein was used as the immunogen for this PKM2 antibody.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the PKM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,ICC/IF: 1:400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Antibody in PBS with 50 % Glycerol and 0.03 % ProClin 300

Lagerung: -20 °C

Informationen zur Lagerung: Store the PKM2 antibody at -20°C.

Details zu PKM2

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Andere Bezeichnung: Pyruvate Kinase / PKM2

Hintergrund: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. [UniProt]

UniProt: P14618

Pathways: Warburg Effekt