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ATG14 Antikörper

Der Kaninchen Polyklonal Anti-ATG14-Antikörper wurde für WB, FACS und IHC (p) validiert. Er ist geeignet, ATG14 in Proben von Human und Ratte zu detektieren.
Produktnummer ABIN4950253

Kurzübersicht für ATG14 Antikörper (ABIN4950253)

Target

Alle ATG14 Antikörper anzeigen
ATG14 (ATG14 Autophagy Related 14 (ATG14))

Reaktivität

  • 35
  • 7
  • 6
  • 1
Human, Ratte

Wirt

  • 27
  • 8
Kaninchen

Klonalität

  • 27
  • 8
Polyklonal

Konjugat

  • 19
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ATG14 Antikörper ist unkonjugiert

Applikation

  • 22
  • 19
  • 12
  • 7
  • 7
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Aufreinigung

    Antigen affinity

    Immunogen

    Amino acids RDRERFIDKKERLSRLKSKQEEFQKEVLKAME of human ATG14L were used as the immunogen for the ATG14L antibody.

    Isotyp

    IgG
  • Applikationshinweise

    Optimal dilution of the ATG14L antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,FACS: 1-3 μg/10^6 cells

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    Lagerung

    -20 °C

    Informationen zur Lagerung

    After reconstitution, the ATG14L antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target

    ATG14 (ATG14 Autophagy Related 14 (ATG14))

    Andere Bezeichnung

    ATG14L

    Hintergrund

    ATG14 (also known as beclin-1-associated autophagy-related key regulator (Barkor) or ATG14L), an essential autophagy-specific regulator of the class III phosphatidylinositol 3-kinase complex, promotes membrane tethering of protein-free liposomes, and enhances hemifusion and full fusion of proteoliposomes reconstituted with the target (t)-SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) syntaxin 17 (STX17) and SNAP29, and the vesicle (v)-SNARE VAMP8 (vesicle-associated membrane protein 8). ATG14 binds to the SNARE core domain of STX17 through its coiled-coil domain, and stabilizes the STX17-SNAP29 binary t-SNARE complex on autophagosomes.

    UniProt

    Q6ZNE5

    Pathways

    Autophagie
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