IRAK1 Antikörper (AA 618-712)

Produktnummer ABIN492547

Dieser Maus Monoklonal Antikörper detektiert spezifisch IRAK1 in WB, IHC (p) und EIA. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für IRAK1 Antikörper (AA 618-712) (ABIN492547)

Target: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IRAK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Klon: 1F12C1

Produktdetails anti-IRAK1 Antikörper

Bindungsspezifität: AA 618-712

Spezifität: Recognizes IRAK1 (618-712).

Produktmerkmale: Synonyms: IRAK-1, IRAK, Interleukin-1 receptor-associated kinase 1

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Recombinant protein corresponding to amino acids 618-712 of Human IRAK.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: IRAK antibody can be used for detection of IRAK at 1 μg/mL. Positive Control: HeLa Lysate. Immunohistochemistry: 2.5 μg/mL. Positive Control: Rat Liver Tissue.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu IRAK1

Target: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Andere Bezeichnung: IRAK1

Hintergrund: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).Synonyms: IRAK, IRAK-1, Interleukin-1 receptor-associated kinase 1

Gen-ID: 3654

UniProt: P51617

Pathways: NF-kappaB Signalweg, TLR Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades