ORAI1 Antikörper (C-Term)

Produktnummer ABIN492545

Der Maus Monoklonal Anti-ORAI1-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, ORAI1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ORAI1 Antikörper (C-Term) (ABIN492545)

Target: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ORAI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Klon: 3F6H5

Produktdetails anti-ORAI1 Antikörper

Bindungsspezifität: C-Term

Spezifität: Recognizes ORAI1. This antibody is predicted to have no cross-reactivity with ORAI2 or ORAI3.

Produktmerkmale: Synonyms: ORAI-1, CRACM1, TMEM142A, Protein orai-1, Transmembrane protein 142A, Calciumrelease-activated calcium channel protein 1

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: A 16 amino acid peptide from near the carboxy terminus of Human ORAI1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: ORAI1 antibody can be used for detection of ORAI1 at 1-2 μg/mL. Positive Control: Human Ovary Tissue Lysate. Immunohistochemistry: 2.5 μg/mL. Positive Control: Human Spleen Tissue.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu ORAI1

Target: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Andere Bezeichnung: ORAI1

Hintergrund: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels (1 for review). ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry (2). It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor (3). ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE.Synonyms: CRACM1, Calcium release-activated calcium channel protein 1, ORAI-1, Protein orai-1, TMEM142A, Transmembrane protein 142A

Gen-ID: 84876

UniProt: Q96D31

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling