XBP1 Antikörper (AA 2-160)

Produktnummer ABIN492537

Dieses Anti-XBP1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von XBP1 in WB, IF und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für XBP1 Antikörper (AA 2-160) (ABIN492537)

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser XBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Klon: 3H1G4

Produktdetails anti-XBP1 Antikörper

Bindungsspezifität: AA 2-160

Spezifität: Recognizes XBP1/TREB5 (2-160).

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse and Rat.

Produktmerkmale: Synonyms: XBP-1, XBP2, X-box-binding protein 1, Tax-responsive element-binding protein 5

Aufreinigung: Immunoaffinity Chromotography.

Immunogen: XBP-1 antibody was raised against recombinant protein corresponding to amino acids 2 to160 of Human XBP-1 (Genbank accession No. BAB82982).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: XBP1 antibody can be used for detection of XBP1 at 0.5-1 μg/mL. Positive Control: XBP-1 Recombinant Protein. Immunocytochemistry: 2 μg/mL. Positive Control: HepG2 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu XBP1

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Andere Bezeichnung: XBP1 / TREB5

Hintergrund: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) (1). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).Synonyms: Tax-responsive element-binding protein 5, X-box-binding protein 1, XBP-1, XBP2

Gen-ID: 7494

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response