MYD88 Antikörper (AA 176-280)

Produktnummer ABIN492527

Der Maus Monoklonal Anti-MYD88-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, MYD88 in Proben von Human und Maus zu detektieren.

Kurzübersicht für MYD88 Antikörper (AA 176-280) (ABIN492527)

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MYD88 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Klon: 2E9C2

Produktdetails anti-MYD88 Antikörper

Bindungsspezifität: AA 176-280

Spezifität: Recognizes MyD88.

Produktmerkmale: Synonyms: Myeloid differentiation primary response protein MyD88

Aufreinigung: Immunoaffinity Chromotography.

Immunogen: Recombinant protein corresponding to amino acids 176 to 280 of Human MyD88(AAC50954).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot: MyD88 antibody can be used for detection of MyD88 at 2-4 μg/mL. Positive Control: Whole cell lysate from EL4 cells. Immunohistochemistry: 2.5 μg/mL
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu MYD88

Target: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Andere Bezeichnung: MYD88

Hintergrund: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues. Additional NamesSynonyms: Myeloid differentiation primary response protein MyD88

Gen-ID: 4615

UniProt: Q99836

Pathways: NF-kappaB Signalweg, TLR Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades