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FLT4 Antikörper

Dieses Maus Monoklonal-Antikörper erkennt spezifisch FLT4 in IHC (p). Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN4915123

Kurzübersicht für FLT4 Antikörper (ABIN4915123)

Target

Alle FLT4 Antikörper anzeigen
FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

Reaktivität

  • 84
  • 55
  • 17
  • 12
Human

Wirt

  • 78
  • 28
  • 9
  • 2
  • 1
Maus

Klonalität

  • 79
  • 39
Monoklonal

Konjugat

  • 63
  • 12
  • 8
  • 6
  • 5
  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser FLT4 Antikörper ist unkonjugiert

Applikation

  • 63
  • 50
  • 42
  • 32
  • 19
  • 17
  • 13
  • 13
  • 13
  • 9
  • 7
  • 5
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

8C1
  • Kreuzreaktivität

    Human

    Aufreinigung

    Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

    Immunogen

    Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody.

    Isotyp

    IgG2a
  • Applikationshinweise

    IHC-P 1:200-400

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.5 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))

    Andere Bezeichnung

    VEGFR3

    Hintergrund

    Synonyms: PCL, FLT-4, FLT41, LMPH1A, VEGFR3, VEGFR-3, Vascular endothelial growth factor receptor 3, Fms-like tyrosine kinase 4, Tyrosine-protein kinase receptor FLT4, FLT4

    Background: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.

    Gen-ID

    2324

    UniProt

    P35916

    Pathways

    RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
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