SPHK2 Antikörper (Long Isoform, N-Term)

Produktnummer ABIN4620350

Produktdetails anti-SPHK2 Antikörper

Target: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Bindungsspezifität: Long Isoform, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPHK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detetcts Sphingosine Kinase 2 (Long Form).

Aufreinigung: Ligand affinity chromatography

Immunogen: Synthetic peptide derived from the N-terminal extension of the Sphingosine Kinase 2-L protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: (1-5 μg/mL). Positive control: Jurkat lysate. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon arrival, aliquot and freeze at -20 °C to -70 °C.

Details zu SPHK2

Target: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Andere Bezeichnung: Sphingosine Kinase 2 / SPK2 (SPHK2 Produkte)

Synonyme: CG2159 antikoerper, CG32484 antikoerper, Dmel\\CG32484 antikoerper, SK2 antikoerper, Sphk2 antikoerper, sk2 antikoerper, DKFZp469F224 antikoerper, SK 2 antikoerper, SK-2 antikoerper, SPK 2 antikoerper, SPK-2 antikoerper, C76851 antikoerper, Sphingosine kinase antikoerper, sphk2 antikoerper, Sphingosine kinase 2 antikoerper, sphingosine kinase 2 antikoerper, sphK2 antikoerper, Sk2 antikoerper, SPHK2 antikoerper, Sphk2 antikoerper

Hintergrund: The long form of sphingosine kinase 2 (Sphk2-L) is a species-specific isoform of the Sphk2 enzyme expressed in human but not in mouse. It is an N-terminal extended form of Sphk2, extended by 36 amino acids. It functions as expected, catalyzing the formation of sphingosine 1-phosphate from sphingosine, however it appears to have a decreased ability to inhibit DNA synthesis as compared to Sphk2-S (short form of Sphk2). Under normal cellular conditions, Sphk2-L does not appear to inhibit DNA synthesis, but under serum deprivation, SphK2-L translocates to the nucleus and accumlates. This accumlation may be involved in the cessation of cell proliferation or apoptosis depending on the cell type.Synonyms: SK2, SPHK2

Gen-ID: 56848

NCBI Accession: NP_064511

UniProt: Q9NRA0

Pathways: VEGF Signaling