SPHK2 Antikörper (C-Term)

Produktnummer ABIN4620337

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SPHK2 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für SPHK2 Antikörper (C-Term) (ABIN4620337)

Target: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPHK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-SPHK2 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to SPHK2.

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide derived from the C-terminal of Sphingosine Kinase 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 200. ELISA. Positive Control: Active Recombinant Sphingosine Kinase Enzyme.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped on dry ice. Store (in aliquots) at -20 °C only.

Details zu SPHK2

Target: SPHK2 (Sphingosine Kinase 2 (SPHK2))

Andere Bezeichnung: Sphingosine Kinase 2 / SPK2

Hintergrund: Sphingosine Kinase 2 (Sphk2) catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate (S1P), an important signaling molecule with intra- and extracellular functions. Inside the cell S1P acts as a signaling molecule like other sphingolipid metabolites like ceramide and sphingosine. S1P has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis. The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors). These receptors couple to multiple G proteins (e.g. S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide range of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction. Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells. S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).Synonyms: SK2, SPHK2

Gen-ID: 56848

NCBI Accession: NP_064511

UniProt: Q9NRA0

Pathways: VEGF Signaling