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TRAF2 Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-TRAF2-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, TRAF2 in Proben von Human zu detektieren.
Produktnummer ABIN392282

Kurzübersicht für TRAF2 Antikörper (C-Term) (ABIN392282)

Target

Alle TRAF2 Antikörper anzeigen
TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Reaktivität

  • 87
  • 32
  • 29
  • 1
  • 1
Human

Wirt

  • 74
  • 14
  • 1
  • 1
Kaninchen

Klonalität

  • 65
  • 25
Polyklonal

Konjugat

  • 46
  • 6
  • 5
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TRAF2 Antikörper ist unkonjugiert

Applikation

  • 70
  • 32
  • 25
  • 22
  • 20
  • 16
  • 14
  • 14
  • 13
  • 6
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon

RB13076
  • Bindungsspezifität

    • 16
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 343-372, C-Term

    Aufreinigung

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    Immunogen

    This TRAF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-372 amino acids from the C-terminal region of human TRAF2.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:1000. IHC-P: 1:10~50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Target

    TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

    Andere Bezeichnung

    TRAF2

    Hintergrund

    TRAF2 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis.

    Molekulargewicht

    55859

    Gen-ID

    7186

    NCBI Accession

    NP_066961

    UniProt

    Q12933

    Pathways

    NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteine
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