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Caspase 3 Antikörper (AA 60-90)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Caspase 3 in WB, IHC (p) und FACS. Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.
Produktnummer ABIN391813

Kurzübersicht für Caspase 3 Antikörper (AA 60-90) (ABIN391813)

Target

Alle Caspase 3 (CASP3) Antikörper anzeigen
Caspase 3 (CASP3)

Reaktivität

  • 219
  • 129
  • 86
  • 18
  • 11
  • 8
  • 8
  • 6
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
Human

Wirt

  • 244
  • 30
  • 3
  • 2
  • 2
Kaninchen

Klonalität

  • 224
  • 56
Polyklonal

Konjugat

  • 177
  • 22
  • 21
  • 7
  • 7
  • 5
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser Caspase 3 Antikörper ist unkonjugiert

Applikation

  • 215
  • 136
  • 101
  • 64
  • 61
  • 55
  • 49
  • 36
  • 29
  • 27
  • 25
  • 10
  • 10
  • 6
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Klon

RB14696
  • Bindungsspezifität

    • 29
    • 16
    • 16
    • 14
    • 12
    • 12
    • 10
    • 9
    • 9
    • 9
    • 8
    • 8
    • 6
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 60-90

    Aufreinigung

    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

    Immunogen

    This Caspase-3 (CASP3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-90 amino acids from the Central region of human Caspase-3 (CASP3).

    Isotyp

    Ig Fraction
  • Applikationshinweise

    WB: 1:2000. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    Haltbarkeit

    6 months
  • Zhao, Xia, Zhang, Xiong, Li, Yan, Chen, Wang, Wang, Gao, Lee, Li, Wang, Zhang, Tao: "Nucleostemin dysregulation contributes to ischemic vulnerability of diabetic hearts: Role of ribosomal biogenesis." in: Journal of molecular and cellular cardiology, Vol. 108, pp. 106-113, (2018) (PubMed).

    Ling, Song, Fan, Feng, Liu, Yang, Wang, Li, Tian, Zhao, Liu, Huang, Hou, Xu, Shi, Li: "Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway." in: International journal of oncology, Vol. 50, Issue 1, pp. 297-309, (2017) (PubMed).

    Guo, Shao, Chen, Xu, Zhang, Liu: "Expression of pituitary tumor-transforming 2 in human glioblastoma cell lines and its role in glioblastoma tumorigenesis." in: Experimental and therapeutic medicine, Vol. 11, Issue 5, pp. 1847-1852, (2016) (PubMed).

    Liu, Xie, Wang, Liu, Liu, Sun, Niu: "Ubenimex inhibits cell proliferation, migration and invasion in renal cell carcinoma: the effect is autophagy-associated." in: Oncology reports, Vol. 33, Issue 3, pp. 1372-80, (2015) (PubMed).

    Tai, Sun, Liu, Ding, Hsia, Bhuta, Thor, Damoiseaux, Liang, Huang: "Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells." in: Molecular cancer therapeutics, Vol. 11, Issue 6, pp. 1320-31, (2012) (PubMed).

  • Target

    Caspase 3 (CASP3)

    Andere Bezeichnung

    Caspase-3 (CASP3)

    Hintergrund

    CASP3 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

    Molekulargewicht

    31608

    Gen-ID

    836

    NCBI Accession

    NP_004337, NP_116786

    UniProt

    P42574

    Pathways

    Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
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