BIRC3 Antikörper (N-Term)

Produktnummer ABIN390069

Dieses Anti-BIRC3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von BIRC3 in WB und IHC (p). Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für BIRC3 Antikörper (N-Term) (ABIN390069)

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BIRC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB2213

Produktdetails anti-BIRC3 Antikörper

Bindungsspezifität: AA 101-131, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This cIAP2 (BIRC3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-131 amino acids from the N-terminal region of human cIAP2 (BIRC3).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-BIRC3 Antikörper (ABIN390069)

Chen, Xie, Gu, Cai, Wang, Xie, Dong, He, Zhong, Lin, Huang: "Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation." in: Scientific reports, Vol. 5, pp. 8293, (2015) (PubMed).

Sun, Liu, Zou, Lan, Sun, Wang, Zhao, Jiang, Liu: "Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer." in: Journal of bioenergetics and biomembranes, (2015) (PubMed).

Details zu BIRC3

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Andere Bezeichnung: cIAP2 (BIRC3)

Hintergrund: BIRC3 is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain.

Molekulargewicht: 68372

Gen-ID: 330

NCBI Accession: NP_001156, NP_892007

UniProt: Q13489

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Activation of Innate immune Response, Toll-Like Receptors Cascades