c-MET Antikörper (pTyr1349)

Produktnummer ABIN389595

Zitiert in 2+ Publikationen. Der Kaninchen Polyklonal anti-c-MET Antikörper (Klon RB5215) (ABIN389595) detektiert spezifisch c-MET in WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für c-MET Antikörper (pTyr1349) (ABIN389595)

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser c-MET Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB5215

Produktdetails anti-c-MET Antikörper

Bindungsspezifität: pTyr1349

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MET Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1349 of human MET.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-c-MET Antikörper (ABIN389595)

Guo, Reinitz, Youssef, Hong, Nathanson, Akhavan, Kuga, Amzajerdi, Soto, Zhu, Babic, Tanaka, Dang, Iwanami, Gini, Dejesus, Lisiero, Huang, Prins, Wen, Robins, Prados, Deangelis, Mellinghoff, Mehta et al.: "An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. ..." in: Cancer discovery, Vol. 1, Issue 5, pp. 442-56, (2012) (PubMed).

Guo, Prins, Dang, Kuga, Iwanami, Soto, Lin, Huang, Akhavan, Hock, Zhu, Kofman, Bensinger, Yong, Vinters, Horvath, Watson, Kuhn, Robins, Mehta, Wen, DeAngelis, Prados, Mellinghoff, Cloughesy, Mischel: "EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy." in: Science signaling, Vol. 2, Issue 101, pp. ra82, (2009) (PubMed).

Details zu c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Andere Bezeichnung: MET

Hintergrund: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.

Molekulargewicht: 155541

Gen-ID: 4233

NCBI Accession: NP_000236, NP_001120972

UniProt: P08581

Pathways: RTK Signalweg, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor