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c-MET Antikörper (pTyr1349)

Name: c-MET Antikörper (pTyr1349)
SKU: ABIN389595
Price: 445.5 EUR
Availability: InStock

MET Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB5215 unconjugated

The anti-MET- Pab (ABIN389595 and ABIN2839608) is used in Western blot to detect MET- in mouse kidney tissue lysate. (c-MET Antikörper (pTyr1349))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (c-MET Antikörper (pTyr1349))

IHC (p)

2 Abbildungen

(2 Referenzen)

Produktnummer ABIN389595

Datenblatt (PDF)

Target Alle c-MET (MET) Antikörper anzeigen

c-MET (MET) (Met Proto-Oncogene (MET))
Bindungsspezifität
49

35

27

21

16

12

11

8

7

7

7

6

5

5

4

4

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pTyr1349
Reaktivität
250

144

98

8

6

4

4

4

2

2

2

1

1

1

1
Human
Wirt
221

39

3

2
Kaninchen
Passende Sekundärantikörper
Klonalität
209

56
Polyklonal
Konjugat
131

20

13

12

9

9

9

9

9

9

8

7

3

3

3

3

3

1

1

1

1

1
Dieser c-MET Antikörper ist unkonjugiert
Applikation
181

105

51

43

31

27

26

23

15

8

8

7

4

4

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen

This MET Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1349 of human MET.

Klon

RB5215

Isotyp

Ig Fraction

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anti-Met Proto-Oncogene (MET) (pTyr1349) antibody
MET Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

WB: 1:1000. IHC-P: 1:50~100

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit

6 months
Guo, Reinitz, Youssef, Hong, Nathanson, Akhavan, Kuga, Amzajerdi, Soto, Zhu, Babic, Tanaka, Dang, Iwanami, Gini, Dejesus, Lisiero, Huang, Prins, Wen, Robins, Prados, Deangelis, Mellinghoff, Mehta et al.: "An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. ..." in: Cancer discovery, Vol. 1, Issue 5, pp. 442-56, (2012) (PubMed).

Guo, Prins, Dang, Kuga, Iwanami, Soto, Lin, Huang, Akhavan, Hock, Zhu, Kofman, Bensinger, Yong, Vinters, Horvath, Watson, Kuhn, Robins, Mehta, Wen, DeAngelis, Prados, Mellinghoff, Cloughesy, Mischel: "EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy." in: Science signaling, Vol. 2, Issue 101, pp. ra82, (2009) (PubMed).
Target

c-MET (MET) (Met Proto-Oncogene (MET))

Andere Bezeichnung

MET (MET Produkte)

Synonyme

AUTS9 antikoerper, HGFR antikoerper, RCCP2 antikoerper, c-Met antikoerper, AI838057 antikoerper, HGF antikoerper, Par4 antikoerper, Hgfr antikoerper, c-met antikoerper, MET antikoerper, C-MET antikoerper, met antikoerper, met-A antikoerper, MET proto-oncogene, receptor tyrosine kinase antikoerper, met proto-oncogene antikoerper, MET proto-oncogene, receptor tyrosine kinase L homeolog antikoerper, MET antikoerper, Met antikoerper, met.L antikoerper

Hintergrund

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.

Molekulargewicht

155541

Gen-ID

4233

NCBI Accession

NP_000236, NP_001120972

UniProt

P08581

Pathways

RTK Signalweg, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor