CDK2 Antikörper (pThr160)

Produktnummer ABIN389540

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-CDK2 Antikörper wird verwendet zum Nachweis von CDK2 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für CDK2 Antikörper (pThr160) (ABIN389540)

Target: CDK2 (Cyclin-Dependent Kinase 2 (CDK2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB7342

Produktdetails anti-CDK2 Antikörper

Bindungsspezifität: pThr160

Homologie: B, Ha, M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Cdk2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T160 of human Cdk2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-CDK2 Antikörper (ABIN389540)

Wang, Liu, Zhao, Song, Wang, Wang, Sun: "Phosphorylation of CDK2 on threonine 160 influences silencing of sex chromosome during male meiosis." in: Biology of reproduction, Vol. 90, Issue 6, pp. 138, (2014) (PubMed).

Details zu CDK2

Target: CDK2 (Cyclin-Dependent Kinase 2 (CDK2))

Andere Bezeichnung: Cdk2

Hintergrund: Cdk2 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.

Molekulargewicht: 33930

Gen-ID: 1017

NCBI Accession: NP_001789, NP_439892

UniProt: P24941

Pathways: PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA