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PCNA Antikörper (C-Term)

Name: PCNA Antikörper (C-Term)
SKU: ABIN389344
Price: 445.5 EUR
Availability: InStock

PCNA Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB17486 unconjugated

Western blot analysis of PCNA Antibody (C-term) (ABIN389344 and ABIN2839453) in Jurkat, Hela, 293 cell line lysates (35 μg/lane).

PCNA Antibody (C-term) (ABIN389344 and ABIN2839453) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.

IHC (p)

Confocal immunofluorescent analysis of PCNA Antibody (C-term) (ABIN389344 and ABIN2839453) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).

Confocal immunofluorescent analysis of PCNA Antibody (C-term) (ABIN389344 and ABIN2839453) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).

Western blot analysis of PCNA (arrow) using rabbit polyclonal PCNA Antibody (C-term) (ABIN389344 and ABIN2839453).

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PCNA antibody (C-term) (ABIN389344 and ABIN2839453) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

IHC (p)

6 Abbildungen

(5 Referenzen)

Produktnummer ABIN389344

Datenblatt (PDF)

Target Alle PCNA Antikörper anzeigen

PCNA (Proliferating Cell Nuclear Antigen (PCNA))
Bindungsspezifität
16

16

16

15

12

10

8

6

3

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 231-261, C-Term
Reaktivität
222

157

156

57

32

28

23

19

19

18

18

16

11

11

7

5

5

4

4

4

4

3

3

3

2

2

2

2

2

1

1

1

1

1
Human
Wirt
142

93

3
Kaninchen
Passende Sekundärantikörper
Klonalität
141

96

1
Polyklonal
Konjugat
119

18

14

9

6

6

5

5

5

5

5

5

5

5

5

5

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Dieser PCNA Antikörper ist unkonjugiert
Applikation
205

68

67

62

60

50

48

40

34

16

15

12

5

4

3

2

2

2

2

2

1

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie

B, Ha, Pr, Rat

Aufreinigung

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen

This PCNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-261 amino acids from the C-terminal region of human PCNA.

Klon

RB17486

Isotyp

Ig Fraction

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PCNA Reaktivität: Human WB, ELISA, IF, IP Wirt: Maus Monoclonal 1G7 unconjugated

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anti-Proliferating Cell Nuclear Antigen (PCNA) (AA 6-261) antibody
PCNA Reaktivität: Human, Maus, Ratte, Schwein, Hund, Kaninchen, Rhesusaffen WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) antibody
PCNA Reaktivität: Human WB, IHC, IHC (p) Wirt: Maus Monoclonal 1H10 unconjugated

anti-Proliferating Cell Nuclear Antigen (PCNA) antibody
PCNA Reaktivität: Human WB, IHC, IF, IP Wirt: Kaninchen Monoclonal unconjugated

Applikationshinweise

IF: 1:10~50. IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50. IHC-P: 1:10~50

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit

6 months
Deng, Xu, Zou, Shen, Peng, Liu, Engelhardt, Yan, Qiu: "DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells." in: Journal of virology, Vol. 91, Issue 1, (2017) (PubMed).

Lei, Li, Luo: "Liuweiwuling tablets attenuate acetaminophen-induced acute liver injury and promote liver regeneration in mice." in: World journal of gastroenterology : WJG, Vol. 21, Issue 26, pp. 8089-95, (2015) (PubMed).

Ding, Ko, Pehar, Kotch, Peters, Luo, Salamat, Puglielli: "Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces ?-secretase (BACE1) levels and A? generation." in: The Journal of biological chemistry, Vol. 287, Issue 11, pp. 8424-33, (2012) (PubMed).

Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: "DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5639-49, (2012) (PubMed).

Li, Li, Zhang, Bai, Wang, Zhao, Jonas: "Lentiviral vector-mediated PAX6 overexpression promotes growth and inhibits apoptosis of human retinoblastoma cells." in: Investigative ophthalmology & visual science, Vol. 52, Issue 11, pp. 8393-400, (2011) (PubMed).
Target

PCNA (Proliferating Cell Nuclear Antigen (PCNA))

Andere Bezeichnung

PCNA (PCNA Produkte)

Synonyme

PCNAR antikoerper, Pcna/cyclin antikoerper, pcna antikoerper, AO090003000846 antikoerper, 53/13 antikoerper, CG9193 antikoerper, DmPCNA antikoerper, Dmel\\CG9193 antikoerper, MUS209 antikoerper, Mus209 antikoerper, PCNA antikoerper, PCNA/mus209 antikoerper, Pcna antikoerper, dPCNA antikoerper, l(2)02448 antikoerper, l(2)56F antikoerper, l(2)56Fa antikoerper, l(2)s1534 antikoerper, cb16 antikoerper, fb36g03 antikoerper, wu:fa28e03 antikoerper, wu:fb36g03 antikoerper, pcna-A antikoerper, proliferating cell nuclear antigen antikoerper, DNA polymerase III sliding clamp antikoerper, Proliferating cell nuclear antigen antikoerper, Proliferating cell nuclear antigen-like antikoerper, proliferating cell nuclear antigen L homeolog antikoerper, proliferating cell nuclear antigen 1 antikoerper, PCNA antikoerper, Pcna antikoerper, pcna antikoerper, MMP_RS08810 antikoerper, ANI_1_512014 antikoerper, AOR_1_1500154 antikoerper, MGC53867 antikoerper, pcna.L antikoerper, pcna1 antikoerper, LOC106420145 antikoerper, pcn1 antikoerper

Hintergrund

PCNA is found in the nucleus and is a cofactor of DNA polymerase delta. This protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway.

Molekulargewicht

28769

Gen-ID

5111

NCBI Accession

NP_002583, NP_872590

UniProt

P12004

Pathways

Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagie