BAX Antikörper (AA 41-76)

Produktnummer ABIN388094

Der Kaninchen Polyklonal Anti-BAX-Antikörper wurde für WB und FACS validiert. Er ist geeignet, BAX in Proben von Human und Maus zu detektieren. Es sind 8+ Publikationen verfügbar.

Kurzübersicht für BAX Antikörper (AA 41-76) (ABIN388094)

Target: BAX (BCL2-Associated X Protein (BAX))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Klon: RB0952

Produktdetails anti-BAX Antikörper

Bindungsspezifität: AA 41-76

Homologie: B

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Bax antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-76 amino acids from human Bax.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. WB: 1:2000. WB: 1:2000. WB: 1:2000. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-BAX Antikörper (ABIN388094)

Cui, Lin, Shi, Pan: "Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf-ERK pathway." in: Biochemical and biophysical research communications, Vol. 491, Issue 2, pp. 277-284, (2017) (PubMed).

Lin, Ma, Wang, Zhao, Liu, Pu, Hu, Hu, Shao: "Edaravone ameliorates compression-induced damage in rat nucleus pulposus cells." in: Life sciences, Vol. 189, pp. 76-83, (2017) (PubMed).

Hu, Kuo, Senadi, Chang, Wang: "Photodynamic Therapy Using Indolines-Fused-Triazoles Induces Mitochondrial Apoptosis in Human Non-Melanoma BCC Cells." in: Anticancer research, Vol. 37, Issue 10, pp. 5499-5505, (2017) (PubMed).

Wang, Wang, Li, Yang, Xing, Chen, Xu: "HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells." in: Molecular medicine reports, Vol. 14, Issue 1, pp. 1026-32, (2016) (PubMed).

Soni, Adebiyi: "Early septic insult in neonatal pigs increases serum and urinary soluble Fas ligand and decreases kidney function without inducing significant renal apoptosis." in: Renal failure, pp. 1-12, (2016) (PubMed).

Li, Wang, Wang, Gao, Zhang, Lu: "Oridonin phosphate-induced autophagy effectively enhances cell apoptosis of human breast cancer cells." in: Medical oncology (Northwood, London, England), Vol. 32, Issue 1, pp. 365, (2014) (PubMed).

Gavathiotis, Reyna, Davis, Bird, Walensky: "BH3-triggered structural reorganization drives the activation of proapoptotic BAX." in: Molecular cell, Vol. 40, Issue 3, pp. 481-92, (2010) (PubMed).

Granado, Gangoiti, Ouro, Arana, Gómez-Muñoz: "Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages." in: Biochimica et biophysica acta, Vol. 1791, Issue 4, pp. 263-72, (2009) (PubMed).

Details zu BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Andere Bezeichnung: Bax

Hintergrund: Bax belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bax forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of the Bax gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.

Molekulargewicht: 21184

Gen-ID: 581

NCBI Accession: NP_004315, NP_620116, NP_620118, NP_620119

UniProt: Q07812

Pathways: p53 Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response