Src Antikörper

Produktnummer ABIN387822

This anti-Src antibody (ABIN387822) is a Mouse Monoclonal antibody detecting Src in WB, IF. Suitable for Human, Mouse.

Kurzübersicht für Src Antikörper (ABIN387822)

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Src Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: 17AT28

Produktdetails anti-Src Antikörper

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This Src antibody is generated from mouse immunized with a recombinant protein of full length human SRC.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:500. WB: 1:2000. WB: 1:100~500. WB: 1:100~500. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-Src Antikörper (ABIN387822)

Nicholson, Seta, Lee, Morgan: "MicroRNA-203 mimics age-related aortic smooth muscle dysfunction of cytoskeletal pathways." in: Journal of cellular and molecular medicine, Vol. 21, Issue 1, pp. 81-95, (2017) (PubMed).

Marcotte, Smith, Sanguin-Gendreau, McDonough, Muller: "Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 8, pp. 2808-13, (2012) (PubMed).

Chen, Li, Zhang, Yi, Chen, Wang, Zhang: "Src-stimulated IRTKS phosphorylation enhances cell migration." in: FEBS letters, Vol. 585, Issue 19, pp. 2972-8, (2011) (PubMed).

Details zu Src

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Andere Bezeichnung: Src

Substanzklasse: Viral Protein

Hintergrund: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Molekulargewicht: 59835

Gen-ID: 6714

NCBI Accession: NP_005408, NP_938033

UniProt: P12931

Pathways: JAK-STAT Signalweg, Neurotrophin Signalübertragung, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagie, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling