Stathmin 1 Antikörper (C-Term)

Produktnummer ABIN374648

Produktdetails anti-Stathmin 1 Antikörper

Target: Stathmin 1 (STMN1)

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Stathmin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody is expected to cross-react with isoform 1a (NP_005554.1, NP_981944.1, NP_981946.1) only. The three reported isoforms (NP_005554.1, NP_981944.1 and NP_981946.1) represent identical protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide (C-KNKESKDPADETEAD) from C-terminus of Human STMN1 (NP_005554.1, NP_981944.1, NP_981946.1)

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1000. Western Blot: 1-3 μg/mL. Immunohistochemistry on Paraffin Sections: 3.75 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-Stathmin 1 Antikörper (ABIN374648)

Watabe-Rudolph, Song, Lausser, Schnack, Begus-Nahrmann, Scheithauer, Rettinger, Otto, Tumani, Thal, Attems, Jellinger, Kestler, von Arnim, Rudolph: "Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease." in: Neurology, Vol. 78, Issue 8, pp. 569-77, (2012) (PubMed).

Wallukat, Muñoz Saravia, Haberland, Bartel, Araujo, Valda, Duchen, Diaz Ramirez, Borges, Schimke: "Distinct patterns of autoantibodies against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon. Their potential impact for early risk assessment in asymptomatic Chagas' patients." in: Journal of the American College of Cardiology, Vol. 55, Issue 5, pp. 463-8, (2010) (PubMed).

Details zu Stathmin 1

Target: Stathmin 1 (STMN1)

Andere Bezeichnung: Stathmin / STMN1 (STMN1 Produkte)

Synonyme: C1orf215 antikoerper, LAP18 antikoerper, Lag antikoerper, OP18 antikoerper, PP17 antikoerper, PP19 antikoerper, PR22 antikoerper, SMN antikoerper, 19k antikoerper, Lap18 antikoerper, Op18 antikoerper, P18 antikoerper, P19 antikoerper, Pig antikoerper, Pp17 antikoerper, Pp18 antikoerper, Pp19 antikoerper, Pr22 antikoerper, Smn antikoerper, prosolin antikoerper, op18 antikoerper, stathmin antikoerper, stmn1 antikoerper, stmn1a antikoerper, lag antikoerper, lap18 antikoerper, pp17 antikoerper, pp19 antikoerper, pr22 antikoerper, smn antikoerper, fj43c10 antikoerper, wu:fj38b07 antikoerper, wu:fj43c10 antikoerper, zgc:110159 antikoerper, cb959 antikoerper, wu:fb14e04 antikoerper, zgc:136942 antikoerper, stmn1-a antikoerper, stmn1b antikoerper, xo35 antikoerper, stathmin 1 antikoerper, stathmin 1 S homeolog antikoerper, stathmin 1b antikoerper, stathmin 1a antikoerper, stathmin-like antikoerper, stathmin antikoerper, stathmin 1 L homeolog antikoerper, STMN1 antikoerper, Stmn1 antikoerper, stmn1.S antikoerper, stmn1 antikoerper, stmn1b antikoerper, stmn1a antikoerper, LOC100229194 antikoerper, stmn1.L antikoerper

Hintergrund: STMN1 is a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Alternatively spliced transcript variants encoding the same protein have been identified.Synonyms: LAP18, Leukemia-associated phosphoprotein p18, Metablastin, OP18, Oncoprotein 18, Op18, Phosphoprotein p19, Prosolin, Protein Pr22, pp17, pp19

Molekulargewicht: 17.3kDa (NP_005554.1, NP_981944.1 and NP_981946.1).

Gen-ID: 3925, 9606

UniProt: P16949

Pathways: MAPK Signalweg, Microtubule Dynamics