Connexin 43/GJA1 Antikörper (pSer368)
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- Target Alle Connexin 43/GJA1 (GJA1) Antikörper anzeigen
- Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))
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Bindungsspezifität
- pSer368
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Reaktivität
- Human, Ratte, Maus, Hund, Rind (Kuh), Huhn, Meerschweinchen, Zebrafisch (Danio rerio)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Connexin 43/GJA1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- Specific for the ~43k Connexin-43 protein phosphorylated at Ser368. Immunolabeling is blocked by λ-phosphatase treatment.
- Kreuzreaktivität (Details)
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Species reactivity (expected):Bovine, Canine, Chicken, Guinea Pig, Human, Mouse and Zebrafish.
Species reactivity (tested):Rat. - Aufreinigung
- Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
- Immunogen
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser368 of rat Connexin-43.
- Isotyp
- IgG
- Top Product
- Discover our top product GJA1 Primärantikörper
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- Applikationshinweise
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Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store the antibody undiluted (in aliquots) at-20 °C.
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- Target
- Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))
- Andere Bezeichnung
- GJA1 / Cx43 (GJA1 Produkte)
- Synonyme
- AVSD3 antikoerper, CX43 antikoerper, DFNB38 antikoerper, GJAL antikoerper, HLHS1 antikoerper, HSS antikoerper, ODDD antikoerper, Cx43 antikoerper, AU042049 antikoerper, AW546267 antikoerper, Cnx43 antikoerper, Cx43alpha1 antikoerper, Gja-1 antikoerper, Npm1 antikoerper, connexin43 antikoerper, cx43a1 antikoerper, gja1 antikoerper, zfCx43.3 antikoerper, connexin 43 antikoerper, gja1-A antikoerper, cx43 antikoerper, gjal antikoerper, oddd antikoerper, dfnb38 antikoerper, gap junction protein alpha 1 antikoerper, gap junction protein, alpha 1 antikoerper, connexin 43 antikoerper, gap junction protein alpha 1 L homeolog antikoerper, CONNEXIN 43 protein antikoerper, GJA1 antikoerper, Gja1 antikoerper, cx43 antikoerper, gja1.L antikoerper, gja1 antikoerper, CONNEXIN 43 antikoerper
- Hintergrund
- Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at Ser368 by protein kinase C (Yogo et al., 2002, Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).Synonyms: Connexin-43, GJAL, Gap junction 43 kDa heart protein, Gap junction alpha-1 protein
- Gen-ID
- 2697
- NCBI Accession
- NP_000156
- UniProt
- P17302
- Pathways
- MAPK Signalweg, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization
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