Connexin 43/GJA1 Antikörper (C-Term)

Produktnummer ABIN372602

Der Kaninchen Polyklonal Anti-Connexin 43/GJA1-Antikörper wurde für WB validiert. Er ist geeignet, Connexin 43/GJA1 in Proben von Human, Ratte, Maus, Hund, Huhn, Zebrafisch (Danio rerio), Schaf, Xenopus laevis, Non-Human Primate und Fink zu detektieren.

Kurzübersicht für Connexin 43/GJA1 Antikörper (C-Term) (ABIN372602)

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Reaktivität: Human, Ratte, Maus, Hund, Huhn, Zebrafisch (Danio rerio), Schaf, Xenopus laevis, Non-Human Primate, Fink

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Connexin 43/GJA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Connexin 43/GJA1 Antikörper

Bindungsspezifität: C-Term

Spezifität: Specific for the ~43k Connexin-43 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Human, Chicken, Canine (Dog), Finch, Mouse, Sheep, Xenopus, Zebrafish and non-Human Primates.
Species reactivity (tested):Rat.

Aufreinigung: Affinity Chromatography.

Immunogen: Peptide corresponding to amino acid residues from the C-terminal region of rat Connexin-43.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Details zu Connexin 43/GJA1

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Andere Bezeichnung: GJA1 / Cx43

Hintergrund: Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002, Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).Synonyms: Connexin-43, GJAL, Gap junction 43 kDa heart protein, Gap junction alpha-1 protein

Gen-ID: 2697

NCBI Accession: NP_000156

UniProt: P17302

Pathways: MAPK Signalweg, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization