CDK1 Antikörper (pTyr15)

Produktnummer ABIN372596

Der Kaninchen Polyklonal anti-CDK1 Antikörper wird verwendet zum Nachweis von CDK1 in Proben von Human, Maus, Ratte, Xenopus laevis und Zebrafisch (Danio rerio). Er wurde validiert für WB.

Kurzübersicht für CDK1 Antikörper (pTyr15) (ABIN372596)

Target: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Reaktivität: Human, Maus, Ratte, Xenopus laevis, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CDK1 Antikörper

Bindungsspezifität: pTyr15

Spezifität: Specific for the ~38k CDC2 protein phosphorylated at Tyr15. Immunolabeling is blocked by the lambda-phosphatase treatment.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat and Zebrafish.
Species reactivity (tested):Human and Xenopus.

Aufreinigung: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Tyr15 of rat CDC2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at-20 °C.

Details zu CDK1

Target: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Andere Bezeichnung: CDK1

Hintergrund: Cdc2 is a highly conserved protein serine kinase that plays a key role in regulation of the cell cycle (Maller, 1991). The ability of cdc2 to exercise control over the cell cycle is dependent upon the phosphorylation of Tyr15 in cdc2 (Nakamizo et al., 2002). cdc2 expression in brain has been linked to both neurogenesis and apoptosis (Konishi and Bonni, 2003, Dranovsky et al., 2001, Okano et al., 1996).Synonyms: CDC2, CDC28A, CDK1, CDKN1, Cell division control protein 2 homolog, Cell division protein kinase 1, Cyclin-dependent kinase 1, P34CDC2, p34 protein kinase

Gen-ID: 983

NCBI Accession: NP_001777

UniProt: P06493

Pathways: Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Toll-Like Receptors Cascades, Synthesis of DNA