CDKN1B Antikörper (AA 8-12)
Kurzübersicht für CDKN1B Antikörper (AA 8-12) (ABIN362757)
Target
Alle CDKN1B Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 8-12
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Spezifität
- The antibody detects endogenous level of total p27Kip1 protein.
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Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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Immunogen
- Peptide sequence around AA 8-12 (N-G-S-P-S) derived from Human p27Kip1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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Isotyp
- IgG
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Applikationshinweise
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Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100 -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C/-20 °C
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Informationen zur Lagerung
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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: "Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression." in: The international journal of biochemistry & cell biology, Vol. 41, Issue 11, pp. 2240-50, (2009) (PubMed).
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: "Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression." in: The international journal of biochemistry & cell biology, Vol. 41, Issue 11, pp. 2240-50, (2009) (PubMed).
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- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
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Andere Bezeichnung
- p27Kip1
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Hintergrund
- Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events.
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Molekulargewicht
- 27 kDa
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NCBI Accession
- NP_004055
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UniProt
- P46527
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Pathways
- Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagie
Target
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