ATM Antikörper (Ataxia Telangiectasia Mutated) (pSer1981)

Details for Product anti-ATM Antibody No. ABIN362100, Anbieter: Anmelden zum Anzeigen
Antigen
  • ATM
  • Atm
  • CG6535
  • Dmel\\CG6535
  • Tefu
  • atm
  • atm/tefu
  • dATM
  • tef
  • Xatm
  • at1
  • atdc
  • tel1
  • telo1
  • AT1
  • ATA
  • ATC
  • ATD
  • ATDC
  • ATE
  • TEL1
  • TELO1
  • AI256621
  • C030026E19Rik
  • telomere fusion
  • ATM serine/threonine kinase L homeolog
  • ATM serine/threonine kinase
  • ataxia telangiectasia mutated
  • ataxia telangiectasia mutated (atm)
  • serine/threonine-protein kinase ATM
  • tefu
  • atm.L
  • atm
  • ATM
  • EDI_100660
  • CpipJ_CPIJ001772
  • BDBG_08252
  • PAAG_02532
  • MCYG_05088
  • VDBG_06833
  • ACLA_015700
  • LOC5565620
  • MGYG_07634
  • PGTG_14279
  • Atm
Epitop
pSer1981
89
36
18
18
16
16
10
7
6
6
6
6
5
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
368
164
86
29
8
1
1
1
Wirt
Kaninchen
241
106
13
8
3
1
Klonalität
Polyklonal
Konjugat
Dieser ATM Antikörper ist unkonjugiert
12
11
9
8
8
6
5
5
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Immunohistochemistry (IHC)
231
143
117
95
84
63
56
45
27
22
13
8
4
4
2
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Peptide sequence around phosphorylation site of pSer1981 (E-G-S (p) -Q-S) derived from Human ATM. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotyp IgG
Spezifität The antibody detects endogenous level of ATM only when phosphorylated at serine 1981.
Reinigung The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Plasmids, Primers & others Plasmide, Primers & weitere ATM products on genomics-online (e.g. as negative or positive controls)
Andere Bezeichnung ATM (ATM Antibody Abstract)
Hintergrund ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene.
Molekulargewicht 350 kDa
NCBI Accession NP_000042
UniProt Q13315
Pathways p53 Signalweg, Apoptose, DNA Reparatur, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
Applikations-hinweise Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100  
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Produkt verwendet in: Inaba, Kuboniwa, Sugita, Lamont, Amano: "Identification of signaling pathways mediating cell cycle arrest and apoptosis induced by Porphyromonas gingivalis in human trophoblasts." in: Infection and immunity, Vol. 80, Issue 8, pp. 2847-57, 2012 (PubMed).

Mahalingam, Tay, Tan, Chai, Wang: "Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts." in: The FEBS journal, Vol. 278, Issue 19, pp. 3724-38, 2011 (PubMed).

Leemput, Masson, Bigot, Errachid, Dansault, Provost, Gadin, Aoufouchi, Menasche, Abitbol: "ATM localization and gene expression in the adult mouse eye." in: Molecular vision, Vol. 15, pp. 393-416, 2009 (PubMed).

Kang, Guo, Tan, Zhao, Tang, Lu: "Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer." in: Mutation research, Vol. 638, Issue 1-2, pp. 17-25, 2008 (PubMed).

Allgemeine Veröffentlichungen Gupta, Sharma, Young, Agarwal, Smith, Paull, Lucchesi, Khanna, Ludwig, Pandita: "Involvement of human MOF in ATM function." in: Molecular and cellular biology, Vol. 25, Issue 12, pp. 5292-305, 2005 (PubMed).

Silverman, Takai, Buonomo, Eisenhaber, de Lange: "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint." in: Genes & development, Vol. 18, Issue 17, pp. 2108-19, 2004 (PubMed).

Nakada, Shimomura, Matsumoto, Sugimoto: "The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment." in: Nucleic acids research, Vol. 31, Issue 6, pp. 1715-24, 2003 (PubMed).

Bernstein, Seminara, Børresen-Dale: "Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002." in: Breast cancer research : BCR, Vol. 4, Issue 6, pp. 249-52, 2002 (PubMed).

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