LBP Antikörper

Produktnummer ABIN343175

Der Maus Monoklonal Anti-LBP-Antikörper wurde für IHC (p) validiert. Er ist geeignet, LBP in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für LBP Antikörper (ABIN343175)

Target: LBP (Lipopolysaccharide Binding Protein (LBP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LBP Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: BiG42

Produktdetails anti-LBP Antikörper

Spezifität: Human LBP (Lipopolysaccaride binding protein). The antibody don't block LPS binding to membrane bound CD14.

Kreuzreaktivität: Rind (Kuh), Hund, Pferd, Kaninchen

Aufreinigung: Protein A affinity column

Immunogen: native human LBP

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA, Immune histology at paraffin sections, LBP inhibition studies, Western Blot. No inhibition of LPS binding to membrane bound CD14 Binding titre at human LBP- ELISA: 1:10.000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with bidistilled water

Konzentration: 1 mg/mL

Buffer: PBS, pH 7.12

Konservierungsmittel: Without preservative

Lagerung: -20 °C,-80 °C

Referenzen für anti-LBP Antikörper (ABIN343175)

Eckert, Kim, Kim, Gürtler, Oh, Sur, Lundvall, Hamann, van der Ploeg, Pickkers, Giamarellos-Bourboulis, Kubarenko, Weber, Kabesch, Kumpf, An, Lee, Schumann: "The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity." in: Immunity, Vol. 39, Issue 4, pp. 647-60, (2013) (PubMed).

Rahman, Lecchi, Avallone, Roccabianca, Sartorelli, Ceciliani: "Lipopolysaccharide-binding protein: Local expression in bovine extrahepatic tissues." in: Veterinary immunology and immunopathology, (2010) (PubMed).

Ren, Jin, Leung: "Local expression of lipopolysaccharide-binding protein in human gingival tissues." in: Journal of periodontal research, Vol. 39, Issue 4, pp. 242-8, (2004) (PubMed).

Details zu LBP

Target: LBP (Lipopolysaccharide Binding Protein (LBP))

Andere Bezeichnung: Lipopolysaccharide (LPS)-Binding Protein (LBP)

Hintergrund: Background: Natural Lipopolysccaride Binding Protein (LBP) is a 58KD glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNFα). It acts as opsonin for GRAM negative cells, LPS, neutrophiles and granulocytes.

Molekulargewicht: ~58kDa

Gen-ID: 3929

NCBI Accession: NP_004130

UniProt: P18428

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process