KLKB1 Antikörper

Produktnummer ABIN342152

Produktdetails anti-KLKB1 Antikörper

Target: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KLKB1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Spezifität: Specifically recognizes in human plasma two variants (88 kD and 85 kD) of prekallikrein and its activation products kallikrein (88 kD and 85 kD), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and antithrombin III, and 45 kD prekallikrein/kallikrein fragment(s). It also recognizes prekallikrein and its activation products in chimpanzee, rhesus, and baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in human and rhesus plasmas by approximately 60-80 % and 55 %, respectively. Does not cross-react with tissue kallikrein.

Aufreinigung: Protein G purified

Immunogen: Human plasma prekallikrein.

Type of Immunogen: Purified protein

Klon: 13G11

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Approved: ELISA, WB

Usage: May be used in ELISA and Western blots to identify/quantitate prekallikrein and its activation products in plasmas of humans, chimpanzees, rhesus monkeys, and baboons. NOTE: Prekallikrein activation may occur with repeated freezing/thawing (3x or more) of plasma samples obtained from humans or other primates.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS,  pH 7.4

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 4°C or -20°C, Avoid freeze-thaw cycles.

Details zu KLKB1

Target: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Andere Bezeichnung: KLKB1 / Plasma Kallikrein (KLKB1 Produkte)

Synonyme: KLK3 antikoerper, PPK antikoerper, APS antikoerper, Kal-3 antikoerper, Kal3 antikoerper, Klk3 antikoerper, PSA antikoerper, KALP15 antikoerper, Kalp1 antikoerper, KLKB1 antikoerper, DKFZp459J2015 antikoerper, klkb1 antikoerper, kallikrein B1 antikoerper, kallikrein B, plasma 1 antikoerper, plasma kallikrein antikoerper, Plasma kallikrein antikoerper, kallikrein B, plasma (Fletcher factor) 1 antikoerper, coagulation factor XI antikoerper, kallikrein B1 L homeolog antikoerper, KLKB1 antikoerper, Klkb1 antikoerper, CpipJ_CPIJ004042 antikoerper, CpipJ_CPIJ014955 antikoerper, CpipJ_CPIJ020108 antikoerper, VAA_02266 antikoerper, LOC100549617 antikoerper, klkb1 antikoerper, klkb1.L antikoerper

Hintergrund: Name/Gene ID: KLKB1
Subfamily: Serine S1
Family: Protease

Synonyms: KLKB1, Fletcher factor deficiency, Fletcher factor, Kininogenin, Plasma kallikrein, PKK deficiency, Plasma kallikrein heavy chain, PPK, Prekallikrein deficiency, Plasma kallikrein light chain, Plasma prekallikrein, Kallikrein 3

Gen-ID: 3818

UniProt: P03952

Pathways: Komplementsystem, Brown Fat Cell Differentiation