E2F1 Antikörper (pSer364)
Kurzübersicht für E2F1 Antikörper (pSer364) (ABIN3201010)
Target
Alle E2F1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- pSer364
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Produktmerkmale
- Product: Mouse monoclonal antibody (clone #2) specific to the human E2F1 protein phosphorylated at Ser364. Produced in serum-free medium and purified under mild conditions
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Aufreinigung
- Purified
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Immunogen
- A synthetic peptide corresponding to a sequence of human E2F1 protein including and surrounding pSer364
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Isotyp
- IgG2b kappa
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Applikationshinweise
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1. Western blotting: ~1 g/mL
2. ELISA
Not tested for other applications. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- PBS (-), 50 % glycerol
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Konservierungsmittel
- Azide free
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Lagerung
- -20 °C/-80 °C
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Informationen zur Lagerung
- -20 C (For long term storage: -70 C)
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- E2F1 (E2F Transcription Factor 1 (E2F1))
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Andere Bezeichnung
- E2F1
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Hintergrund
- E2F1 is a member of E2F group of proteins that share common structural and functional domains and plays a major role during the G1/S transition in the mammalian cell cycle as a transcriptional factor. E2F1 is regulated during cell cycle progression. It is phosphorylated at Ser364 by Chk2 kinase in response to DNA damage, stabilized, mobilized to nucleus and activated as a transcription factor. It induces apoptosis by activating transcription of the p53 homolog, p73. E2F1 protein consists of 437 amino acids with a molecular mass of 46 kDa.
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UniProt
- Q01094
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Pathways
- p53 Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagie
Target
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