Connexin 43/GJA1 Antikörper (pSer368)

Produktnummer ABIN319138

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Connexin 43/GJA1 in WB. Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus, Hund, Rind (Kuh), Huhn, Meerschweinchen und Zebrafisch (Danio rerio).

Kurzübersicht für Connexin 43/GJA1 Antikörper (pSer368) (ABIN319138)

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Huhn, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Connexin 43/GJA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Connexin 43/GJA1 Antikörper

Bindungsspezifität: pSer368

Spezifität: This antibody specifically recognises 43 kDa Connexin43, when phosphorylated at Ser368.

Aufreinigung: Affinity chromatography

Immunogen: Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 1000, detects a band of approximately 43 kDa in rat hippocampus celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES, pH 7.5 containing 0.09 % Sodium Azide, 0.01 % Bovine Serum Albumin, 50 % Glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Connexin 43/GJA1

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Andere Bezeichnung: GJA1 / Cx43

Hintergrund: Connexin43 (CX43) allows for the exchange of solutions between neighbouring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. Studies suggest that a decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C (PKC). A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumours and peritumoural reactive astrocytes (3).Synonyms: Connexin-43, GJAL, Gap junction 43 kDa heart protein, Gap junction alpha-1 protein

Gen-ID: 2697

NCBI Accession: NP_000156

UniProt: P17302

Pathways: MAPK Signalweg, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization