Prothrombin Antikörper
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- Target Alle Prothrombin (F2) Antikörper anzeigen
- Prothrombin (F2) (Coagulation Factor II (thrombin) (F2))
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Prothrombin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of Prothrombin protein.(region surrounding Gly724)
- Aufreinigung
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product F2 Primärantikörper
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- Applikationshinweise
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Western Blot: 1/500-1/1000. ELISA: 1/10000-1/20000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- Prothrombin (F2) (Coagulation Factor II (thrombin) (F2))
- Andere Bezeichnung
- Prothrombin (F2) (F2 Produkte)
- Synonyme
- PT antikoerper, RPRGL2 antikoerper, THPH1 antikoerper, Cf-2 antikoerper, Cf2 antikoerper, FII antikoerper, thrombin antikoerper, zgc:66319 antikoerper, wu:fb57c10 antikoerper, wu:fd42e09 antikoerper, wu:fd59d01 antikoerper, prothrombin antikoerper, F2 antikoerper, coagulation factor II, thrombin antikoerper, coagulation factor II antikoerper, coagulation factor II (thrombin) antikoerper, F2 antikoerper, f2 antikoerper
- Hintergrund
- Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which mediate a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Proteolytic cleavage of Prothrombin (Factor II) at residue 44 leads to formation of Thrombin in the first step of the coagulation cascade. Thrombin cleaves bonds between Arg and Gly and activates Factors V, VII, VIII and XIII in complex with thrombomodulin and Protein C. Thrombin maintains vascular integrity during development and postnatal life and coordinates connective tissue proteins by stimulating fibroblast procollagen production.Synonyms: Coagulation factor II
- Molekulargewicht
- approx. 70 kDa
- Gen-ID
- 2147
- NCBI Accession
- NP_000497
- UniProt
- P00734
- Pathways
- Komplementsystem, Peptide Hormone Metabolism, Regulation of G-Protein Coupled Receptor Protein Signaling
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