CHEK1 Antikörper
Kurzübersicht für CHEK1 Antikörper (ABIN306587)
Target
Alle CHEK1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- Sheep anti Human chk 1 kinase
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Produktmerkmale
- One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic-dependent kinase cdc2, which regulates entry in to mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of cdc2. It is hypothesized that chk 1 induces serine 216 phosphorylation of Cdc 25C and subsequent binding negatively regulated Cdc25C, thus preventing it from activating cdc2.
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Aufreinigung
- Ammonium Sulfate Precipitation
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Isotyp
- IgG
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Applikationshinweise
- Western Blot at 1 - 10 μg/mL.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- CHEK1 (Checkpoint Kinase 1 (CHEK1))
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Andere Bezeichnung
- chk 1 kinase
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Hintergrund
- Sheep anti human chk 1 kinase, checkpoint kinase 1
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UniProt
- O14757
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Pathways
- p53 Signalweg, Apoptose, Zellzyklus, DNA Reparatur
Target
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