CHEK1 Antikörper

Produktnummer ABIN306587

Der Schaf Polyklonal Anti-CHEK1-Antikörper wurde für validiert. Er ist geeignet, CHEK1 in Proben von Human, Maus, Ratte und Affe zu detektieren.

Kurzübersicht für CHEK1 Antikörper (ABIN306587)

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser CHEK1 Antikörper ist unkonjugiert

Applikation: Bitte anfragen

Produktdetails anti-CHEK1 Antikörper

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Details zu CHEK1

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Andere Bezeichnung: chk 1 kinase

Hintergrund: The immunogen for anti-human chk-1 was a GST fusion protein corresponding to amino acid sequence 1-474 and having a molecular weight of 54 kD. One mechanism by which checkpoints maintain the fidelity of cell cycle events is through blocking mitosis in response to unreplicated or damaged DNA. In most species this occurs through inhibiting activation of the cyclic-dependent kinase cdc2, which regulates entry in to mitosis. Chk1, a kinase involved in the DNA damage checkpoint response can phosphorylate Cdc25C an activator of cdc2. It is hypothesized that chk 1 induces serine 216 phosphorylation of Cdc 25C and subsequent binding negatively regulated Cdc25C, thus preventing it from activating cdc2. Synonyms: sheep anti human chk 1 kinase, checkpoint kinase 1.

UniProt: O14757

Pathways: p53 Signalweg, Apoptose, Zellzyklus, DNA Reparatur