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ATF2 Antikörper (AA 93-450)

Dieses Anti-ATF2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ATF2 in WB, IHC, IHC (fro) und FACS. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN3043791

Kurzübersicht für ATF2 Antikörper (AA 93-450) (ABIN3043791)

Target

Alle ATF2 Antikörper anzeigen
ATF2 (Activating Transcription Factor 2 (ATF2))

Reaktivität

  • 303
  • 234
  • 200
  • 17
  • 12
  • 11
  • 8
  • 7
  • 7
  • 5
  • 5
  • 3
  • 2
  • 2
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 331
  • 15
  • 2
  • 1
Kaninchen

Klonalität

  • 319
  • 30
Polyklonal

Konjugat

  • 163
  • 18
  • 11
  • 11
  • 9
  • 9
  • 9
  • 9
  • 9
  • 9
  • 9
  • 9
  • 9
  • 9
  • 9
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 3
  • 2
Dieser ATF2 Antikörper ist unkonjugiert

Applikation

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  • 86
  • 64
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  • 42
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  • 18
  • 15
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  • 6
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
  • Bindungsspezifität

    • 42
    • 39
    • 26
    • 25
    • 25
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    • 24
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    • 15
    • 14
    • 14
    • 13
    • 13
    • 11
    • 9
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    • 5
    • 5
    • 5
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    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 93-450

    Verwendungszweck

    Anti-ATF2 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-ATF2 Antibody Picoband® (ABIN3043791). Tested in Flow Cytometry, IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E.coli-derived human ATF2 recombinant protein (Position: E93-E450). Human ATF2 shares 99% amino acid (aa) sequence identity with both mouse and rat ATF2.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Mouse, Rat
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. "Entrez Gene: ATF2 activating transcription factor 2" 2. Bhoumik A, Takahashi S, Breitweiser W, Shiloh Y, Jones N, Ronai Z (May 2005). "ATM-dependent phosphorylation of ATF2 is required for the DNA damage response". Mol. Cell 18 (5): 577-87.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    ATF2 (Activating Transcription Factor 2 (ATF2))

    Andere Bezeichnung

    ATF2

    Hintergrund

    Synonyms: Cyclic AMP-dependent transcription factor ATF-2,cAMP-dependent transcription factor ATF-2,2.3.1.48 ,Activating transcription factor 2,Cyclic AMP-responsive element-binding protein 2,CREB-2,cAMP-responsive element-binding protein 2,HB16,Histone acetyltransferase ATF2,cAMP response element-binding protein CRE-BP1,ATF2,CREB2, CREBP1,

    Tissue Specificity: Ubiquitously expressed, with more abundant expression in the brain.

    Background: ATF2, also known as Activating transcription factor 2, is a protein that in humans is encoded by the ATF2 gene. It is mapped to 2q31.1. This gene encodes a transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro, thus, it may represent a class of sequence-specific factors that activate transcription by effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined.

    Sequence Similarities: Belongs to the bZIP family. ATF subfamily.

    Molekulargewicht

    65-70 kDa

    Gen-ID

    1386

    UniProt

    P15336

    Pathways

    MAPK Signalweg, RTK Signalweg, Thyroid Hormone Synthesis, Activation of Innate immune Response, Chromatin Binding, Myometrial Relaxation and Contraction, Synaptic Membrane, Tube Formation, Toll-Like Receptors Cascades
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