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Caspase 1 Antikörper (N-Term)

CASP1 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043221
  • Target Alle Caspase 1 (CASP1) Antikörper anzeigen
    Caspase 1 (CASP1)
    Bindungsspezifität
    • 11
    • 9
    • 8
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 135-152, N-Term
    Reaktivität
    • 108
    • 40
    • 35
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 127
    • 12
    • 4
    • 1
    Kaninchen
    Klonalität
    • 116
    • 28
    Polyklonal
    Konjugat
    • 97
    • 23
    • 9
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Caspase 1 Antikörper ist unkonjugiert
    Applikation
    • 115
    • 71
    • 47
    • 32
    • 24
    • 21
    • 20
    • 5
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Verwendungszweck
    Anti-Caspase-1(P20)/CASP1 Antibody Picoband®
    Sequenz
    CSLEEAQRIW KQKSAEIY
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-Caspase-1 (P20)/CASP1 Antibody (ABIN3043221). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human CASP1.
    Isotyp
    IgG
    Top Product
    Discover our top product CASP1 Primärantikörper
  • Applikationshinweise
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. Cerretti, D. P., Hollingsworth, L. T., Kozlosky, C. J., Valentine, M. B., Shapiro, D. N., Morris, S. W., Nelson, N.Molecular characterization of the gene for human interleukin-1-beta converting enzyme (IL1BC).Genomics 20: 468-473, 1994. 2. Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J., Elliston, K. O., Ayala, J. M., Casano, F. J., Chin, J., Ding, G. J.-F., Egger, L. A., Gaffney, E. P., Limjuco, G., Palyha, O. C., Raju, S. M., Rolando, A. M., Salley, J. P., Yamin, T.-T., Lee, T. D., Shively, J. E., MacCross, M., Mumford, R. A., Schmidt, J. A., Tocci, M. J.A novel heterodimeric cysteine protease is required for interleukin-1-beta processing in monocytes.Nature 356: 768-774, 1992.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Xu, Liu, Zhang, Wang, Wang, Yang, Huo, Sun: "Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy." in: Neural regeneration research, Vol. 7, Issue 17, pp. 1318-24, (2015) (PubMed).

    Lu, Yuan, Ou, Cai, Wang, Sun, Zhang: "Autophagy and apoptosis during adult adipose-derived stromal cells differentiation into neuron-like cells in vitro." in: Neural regeneration research, Vol. 7, Issue 16, pp. 1205-12, (2015) (PubMed).

    Chen, Peng, Rowat, Gao, Zhang, Wang, Zhang, Wang, Qu: "The effect of concentration and duration of normobaric oxygen in reducing caspase-3 and -9 expression in a rat-model of focal cerebral ischaemia." in: Brain research, Vol. 1618, pp. 205-11, (2015) (PubMed).

    Ji, Yan, Li, Lai, Liu: "Therapeutic effects of intrathecal versus intravenous monosialoganglioside against bupivacaine-induced spinal neurotoxicity in rats." in: Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie, Vol. 69, pp. 311-6, (2015) (PubMed).

    Wu, Wang, Hou: "Alpha B-crystallin improved survival of retinal ganglion cells in a rat model of acute ocular hypertension." in: Neural regeneration research, Vol. 7, Issue 19, pp. 1493-7, (2015) (PubMed).

    Wang, Qu, Zhang, Zhang: "Testosterone suppresses ventricular remodeling and improves left ventricular function in rats following myocardial infarction." in: Experimental and therapeutic medicine, Vol. 9, Issue 4, pp. 1283-1291, (2015) (PubMed).

    Liu, Chen, Wang, Yang, Xue, Zhu: "Msi1 confers resistance to TRAIL by activating ERK in liver cancer cells." in: FEBS letters, Vol. 589, Issue 8, pp. 897-903, (2015) (PubMed).

    Peng, Liu, Wei, Lv, Wang, Xiong, Wang, Altaf, Wang, He, Wang, Qu: "P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation." in: International journal of molecular medicine, Vol. 35, Issue 5, pp. 1179-88, (2015) (PubMed).

    Zhang, Yan, Hu, Zhuang, Yu, Hang: "Increased Expression of NLRP3 Inflammasome in Wall of Ruptured and Unruptured Human Cerebral Aneurysms: Preliminary Results." in: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Vol. 24, Issue 5, pp. 972-9, (2015) (PubMed).

    Huang, Huang, Xiao, Yang, Lin, Diao: "Kallistatin, a novel anti-angiogenesis agent, inhibits angiogenesis via inhibition of the NF-?B signaling pathway." in: Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie, Vol. 68, Issue 4, pp. 455-61, (2014) (PubMed).

    Mao, Song, Li, Lv, Zhao, Li, Feng, Chen: "8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury." in: Neural regeneration research, Vol. 8, Issue 2, pp. 133-42, (2014) (PubMed).

    Dai, Li, Tang, Li, Xiao: "Colistin-induced nephrotoxicity in mice involves the mitochondrial, death receptor, and endoplasmic reticulum pathways." in: Antimicrobial agents and chemotherapy, Vol. 58, Issue 7, pp. 4075-85, (2014) (PubMed).

    Yuan, Sun, Ou, Wang, Zhang, Deng, Wu, Zhang: "Apoptosis is an obstacle to the differentiation of adipose-derived stromal cells into astrocytes." in: Neural regeneration research, Vol. 9, Issue 8, pp. 837-44, (2014) (PubMed).

    Chen, Dang, Wang, Tang, Liu, Wu: "The in vitro and in vivo anti-tumor effects of MTX-Fe3O 4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO2." in: Science China. Life sciences, Vol. 57, Issue 7, pp. 698-709, (2014) (PubMed).

    Shu, Yu, Zhang, Liu, Wu, Zang, Yang, Zhou, Yin: "Expression of TRPV1 in cortical lesions from patients with tuberous sclerosis complex and focal cortical dysplasia type IIb." in: Brain & development, Vol. 35, Issue 3, pp. 252-60, (2013) (PubMed).

    Li, Peng, Song, Liang, Mei, Fang: "Electro-acupuncture combined with transcranial magnetic stimulation improves learning and memory function of rats with cerebral infarction by inhibiting neuron cell apoptosis." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 32, Issue 5, pp. 746-9, (2012) (PubMed).

    Li, Li, Huang, Kan, Wang, Wu, Yin, Yao: "Dexamethasone and A???-?? accelerate learning and memory impairments due to elevate amyloid precursor protein expression and neuronal apoptosis in 12-month male rats." in: Behavioural brain research, Vol. 227, Issue 1, pp. 142-9, (2011) (PubMed).

    Fu, Zhao, Wu, Wu, Xu, Liu, Tong: "Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure." in: Journal of ethnopharmacology, Vol. 139, Issue 1, pp. 26-33, (2011) (PubMed).

    Zhao, Wu, Wu, Jia, Gao, Yan, Wang: "Introduction of hypoxia-targeting p53 fusion protein for the selective therapy of non-small cell lung cancer." in: Cancer biology & therapy, Vol. 11, Issue 1, pp. 95-107, (2011) (PubMed).

    Ding, Zou, Li, Tian, Abdelalim, Du, She, Wang, Tan, Wang, Chen, Lv, Chang: "Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect." in: PLoS ONE, Vol. 6, Issue 5, pp. e20008, (2011) (PubMed).

  • Target
    Caspase 1 (CASP1)
    Andere Bezeichnung
    CASP1 (CASP1 Produkte)
    Hintergrund

    Synonyms: Caspase-1,CASP-1,3.4.22.36,Interleukin-1 beta convertase,IL-1BC,Interleukin-1 beta-converting enzyme,ICE,IL-1 beta-converting enzyme,p45,Caspase-1 subunit p20,Caspase-1 subunit p10,CASP1,IL1BC, IL1BCE,

    Tissue Specificity: Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. .

    Background: Caspase 1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, IL18, and IL33 precursor proteins. It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue. The Caspase1 gene consists of 10 exons spanning at least 10.6 kb. The Caspase 1 gene is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages.

    Sequence Similarities: Belongs to the peptidase C14A family.

    Molekulargewicht
    45 kDa
    UniProt
    P29466
    Pathways
    Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome
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