TLR10 Antikörper (N-Term)

Produktnummer ABIN3042981

Dieses Anti-TLR10-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TLR10 in WB. Geeignet für Human.

Kurzübersicht für TLR10 Antikörper (N-Term) (ABIN3042981)

Target: TLR10 (Toll-Like Receptor 10 (TLR10))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLR10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TLR10 Antikörper

Bindungsspezifität: AA 88-102, N-Term

Verwendungszweck: Anti-Toll-like receptor 10 TLR10 Antibody Picoband®

Sequenz: DLKTFEFNKE LRYLD

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Toll-like receptor 10 TLR10 Antibody (ABIN3042981). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human TLR10.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human
1. Chuang, T.-H., Ulevitch, R. J. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim. Biophys. Acta 1518: 157-161, 2001. 2. Hasan, U., Chaffois, C., Gaillard, C., Saulnier, V., Merck, E., Tancredi, S., Guiet, C., Briere, F., Vlach, J., Lebecque, S., Trinchieri, G., Bates, E. E. M. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J. Immun. 174: 2942-2950, 2005. 3. Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., Liu, Y.-J. Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194: 863-869, 2001.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu TLR10

Target: TLR10 (Toll-Like Receptor 10 (TLR10))

Andere Bezeichnung: TLR10

Hintergrund:

Synonyms: Toll-like receptor 10,CD290,TLR10,UNQ315/PRO358,

Tissue Specificity: Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Background: TLR10 (Toll-like receptor 10), is a protein that in humans is encoded by the TLR10 gene. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. By genomic sequence analysis, Hasan et al. (2005) determined that the TLR10 gene is clustered with TLR1 and TLR6 on chromosome 4p14. By coimmunoprecipitation analysis, Hasan et al. (2005) found that TLR10 associated with itself and with TLR1 and TLR2, but not with MD2. Signaling studies showed that TLR10 required MYD88, but not TIRAP, TRAM (TICAM2), or TRIF (TICAM1), to activate immune system promoters. Pro674 within the TLR10 TIR domain was required to activate all promoter examined.

Sequence Similarities: Belongs to the Toll-like receptor family.

Molekulargewicht: 60 kDa

Pathways: TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades