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IL-18 Antikörper (AA 36-192)

Dieses Anti-IL-18-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IL-18 in WB, IHC und ELISA. Geeignet für Maus. Dieses Primary Antibody wurde in 3+ Publikationen zitiert.
Produktnummer ABIN3042801

Kurzübersicht für IL-18 Antikörper (AA 36-192) (ABIN3042801)

Target

Alle IL-18 (IL18) Antikörper anzeigen
IL-18 (IL18) (Interleukin 18 (IL18))

Reaktivität

  • 100
  • 37
  • 36
  • 16
  • 9
  • 9
  • 6
  • 5
  • 3
  • 2
  • 1
  • 1
  • 1
Maus

Wirt

  • 128
  • 62
  • 4
  • 2
  • 1
  • 1
Kaninchen

Klonalität

  • 122
  • 71
  • 3
Polyklonal

Konjugat

  • 118
  • 20
  • 13
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser IL-18 Antikörper ist unkonjugiert

Applikation

  • 133
  • 100
  • 79
  • 76
  • 41
  • 26
  • 17
  • 17
  • 11
  • 8
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • Bindungsspezifität

    • 39
    • 13
    • 11
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 36-192

    Verwendungszweck

    Anti-Interleukin-18 IL18 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    < a href="https://www.bosterbio.com/anti-il-18-antibody-pa1342-boster.html" style="color:#EA8D28">Anti-Interleukin-18 IL18 Antibody (ABIN3042801). Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    E. coli-derived mouse IL-18 recombinant protein (Position: N36-S192).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Mouse
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse
    ELISA, 0.1-0.5 μg/mL, -
    1. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K (November 1995). "Cloning of a new cytokine that induces IFN-gamma production by T cells". Nature 378 (6552): 88-91. 2. Nolan KF, Greaves DR, Waldmann H (July 1998). "The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci". Genomics 51 (1): 161-3.. 3. "Entrez Gene: IL18 interleukin 18 (interferon-gamma-inducing factor)". 4. Nolan, K. F., Greaves, D. R., Waldmann, H. The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci. Genomics 51: 161-163, 1998.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Si, Zhang, Gao, Chen, Zhao, Cheng: "Effects of IFN-? on IL-18 Expression in Pregnant Rats and Pregnancy Outcomes." in: Asian-Australasian journal of animal sciences, Vol. 26, Issue 10, pp. 1399-405, (2014) (PubMed).

    Wang, Zhang, Zhang, Xu, Fang: "Expression and localization of IL-18 in the hypothalamic-pituitary-ovarian axis of non-pregnant, pregnant, and abortive rats." in: Journal of reproductive immunology, Vol. 92, Issue 1-2, pp. 45-53, (2011) (PubMed).

    Yang, Shen, Chen, Ge: "Role of interleukin 18 in acute lung inflammation induced by gut ischemia reperfusion." in: World journal of gastroenterology, Vol. 11, Issue 29, pp. 4524-9, (2005) (PubMed).

  • Target

    IL-18 (IL18) (Interleukin 18 (IL18))

    Andere Bezeichnung

    IL18

    Hintergrund

    Synonyms: Interleukin-18,IL-18,Interferon gamma-inducing factor,IFN-gamma-inducing factor,Interleukin-1 gamma,IL-1 gamma,Il18,Igif,

    Tissue Specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.

    Background: Interleukin-18 also known as IL18 is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine.IL-18 is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-gamma (IFN-gamma) or type II interferon that plays an important role in activating the macrophages or other cells.The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci.

    Sequence Similarities: Belongs to the IL-10 family.

    Molekulargewicht

    22 kDa

    UniProt

    P70380

    Pathways

    Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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