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RAB8A Antikörper (C-Term)

Der Kaninchen Polyklonal Anti-RAB8A-Antikörper wurde für WB und IHC validiert. Er ist geeignet, RAB8A in Proben von Human zu detektieren.
Produktnummer ABIN3042554

Kurzübersicht für RAB8A Antikörper (C-Term) (ABIN3042554)

Target

Alle RAB8A Antikörper anzeigen
RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Reaktivität

  • 38
  • 14
  • 13
  • 6
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 22
  • 12
  • 3
Kaninchen

Klonalität

  • 24
  • 14
Polyklonal

Konjugat

  • 24
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
Dieser RAB8A Antikörper ist unkonjugiert

Applikation

  • 21
  • 9
  • 8
  • 6
  • 6
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 170-183, C-Term

    Verwendungszweck

    Anti-Ras-related protein Rab-8A RAB8A Antibody Picoband®

    Sequenz

    KAKMDKKLEG NSPQ

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Ras-related protein Rab-8A RAB8A Antibody (ABIN3042554). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human RAB8A, identical to the related mouse and rat sequences.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    1. "Entrez Gene: RAB8A RAB8A, member RAS oncogene family" 2. Tsang, W. Y., Bossard, C., Khanna, H., Peranen, J., Swaroop, A., Malhotra, V., Dynlacht, B. D. CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficiency in human ciliary disease. Dev. Cell 15: 187-197, 2008. 3. Nimmo ER, Sanders PG, Padua RA, Hughes D, Williamson R, Johnson KJ (October 1991). "The MEL gene: a new member of the RAB/YPT class of RAS-related genes". Oncogene 6 (8): 1347-51.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    Konservierungsmittel

    Thimerosal (Merthiolate), Sodium azide

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

    Andere Bezeichnung

    RAB8A

    Hintergrund

    Synonyms: Ras-related protein Rab-8A,Oncogene c-mel,RAB8A,MEL, RAB8,

    Tissue Specificity: Expressed in brain, placenta and lung. .

    Background: Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene. It is mapped to 19p13.12. The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. RAB8A regulates cilia assembly by targeting and promoting fusion of vesicles near the ciliary membrane. This gene requires CEP290 for centrosome localization and that CEP290 regulates entry of RAB8A into the cilium during assembly of this organelle. RAB8A has been shown to interact with Optineurin and MAP4K2.

    Sequence Similarities: Belongs to the beta-catenin family.

    Molekulargewicht

    24 kDa

    UniProt

    P61006

    Pathways

    M Phase, Regulation of long-term Neuronal Synaptic Plasticity, SARS-CoV-2 Protein Interaktom
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