FOXO1 Antikörper (AA 456-655)

Produktnummer ABIN3042403

Produktdetails anti-FOXO1 Antikörper

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Bindungsspezifität: AA 456-655

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Forkhead box protein O1(FOXO1) detection. Tested with WB in Human,Rat.

Kreuzreaktivität (Details): Predicted Cross Reactivity: human
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Forkhead box protein O1(FOXO1) detection. Tested with WB in Human,Rat.
Gene Name: forkhead box O1
Protein Name: Forkhead box protein O1

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human FOXO1A recombinant protein (Position: N456-G655). Human FOXO1A shares 93% amino acid (aa) sequence identity with both mouse and rat FOXO1A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, The detection limit for FOXO1A is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-FOXO1 Antikörper (ABIN3042403)

Dong, Mai, Zhang, Mi, Wu, Chu, Yang, Sun: "MiR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1." in: Acta biochimica et biophysica Sinica, Vol. 46, Issue 7, pp. 565-71, (2014) (PubMed).

Details zu FOXO1

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Andere Bezeichnung: FOXO1 (FOXO1 Produkte)

Synonyme: FKH1 antikoerper, FKHR antikoerper, FOXO1A antikoerper, FoxO1a.1 antikoerper, foxo1 antikoerper, zgc:153388 antikoerper, Fkhr antikoerper, Foxo1a antikoerper, AI876417 antikoerper, Afxh antikoerper, Fkhr1 antikoerper, fkh1 antikoerper, fkhr antikoerper, foxo1a antikoerper, xFoxO1 antikoerper, FoxO1A antikoerper, foxo1a.2 antikoerper, forkhead box O1 antikoerper, forkhead box O1 a antikoerper, forkhead box O1 L homeolog antikoerper, forkhead box O1 b antikoerper, FOXO1 antikoerper, foxo1a antikoerper, Foxo1 antikoerper, foxo1 antikoerper, foxo1.L antikoerper, foxo1b antikoerper

Hintergrund: Forkhead box protein O1, also known as FKHR or FOXO1A, is a protein that in humans is encoded by the FOXO1 gene. It is mapped to 13q14.11. This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. FOXO1 plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to adipogenesis. This gene is primarily regulated through phosphorylation on multiple residues. Its transcriptional activity is dependent on its phosphorylation state. What's more, FOXO1 may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.

Synonyms: FKH 1 antibody|FKH1 antibody|FKHR antibody|Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma) antibody|Forkhead box O1 antibody|Forkhead box protein O1 antibody|Forkhead box protein O1A antibody|Forkhead in rhabdomyosarcoma antibody|Forkhead, Drosophila, homolog of, in rhabdomyosarcoma antibody|FoxO transcription factor antibody|foxo1 antibody|FOXO1_HUMAN antibody|FOXO1A antibody|OTTHUMP00000018301 antibody

Gen-ID: 2308

UniProt: Q12778

Pathways: PI3K-Akt Signalweg, Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling