IRAK1 Antikörper (N-Term)

Produktnummer ABIN3031488

Der Kaninchen Polyklonal anti-IRAK1 Antikörper (ABIN3031488) detektiert spezifisch IRAK1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für IRAK1 Antikörper (N-Term) (ABIN3031488)

Target: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRAK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-IRAK1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: IRAK1 Antibody

Sequenz: FLYEVPPWVM CRFYKVMDAL

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human IRAK (FLYEVPPWVMCRFYKVMDAL) was used as the immunogen for this IRAK1 antibody (100% homologous in human, mouse and rat).

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the IRAK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the IRAK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu IRAK1

Target: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Andere Bezeichnung: IRAK1

Hintergrund: Interleukin-1 receptor-associated kinase 1, is an enzyme that in humans is encoded by the IRAK1 gene. By radiation hybrid analysis, this gene is mapped to chromosome Xq28. Serine/threonine-protein kinases play a critical roles in initiating innate immune response against foreign pathogens. This gene is involved in Toll-like receptor (TLR) and IL-1R signaling pathways. It encodes one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B.

UniProt: P51617

Pathways: NF-kappaB Signalweg, TLR Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades