Caspase 1 Antikörper (N-Term, Subunit p20)

Produktnummer ABIN3030287

Der Kaninchen Polyklonal Anti-Caspase 1-Antikörper wurde für WB validiert. Er ist geeignet, Caspase 1 in Proben von Maus und Ratte zu detektieren.

Kurzübersicht für Caspase 1 Antikörper (N-Term, Subunit p20) (ABIN3030287)

Target: Caspase 1 (CASP1)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Caspase 1 Antikörper

Bindungsspezifität: N-Term, Subunit p20

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of mouse CASP1 (LEKAQKLWKENPSEIYPIMNT) was used as the immunogen for this Caspase-1 antibody. This sequence is from the p20 subunit.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the Caspase-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Caspase-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Caspase 1

Target: Caspase 1 (CASP1)

Andere Bezeichnung: Caspase-1

Hintergrund: Caspase-1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, IL-18, and IL-33 precursor proteins. It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue. The Caspase-1 gene consists of 10 exons spanning at least 10.6 kb and is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages.

UniProt: P29452

Pathways: Apoptose, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome