TLR5 Antikörper (C-Term)

Produktnummer ABIN302879

Der Kaninchen Polyklonal anti-TLR5 Antikörper wird verwendet zum Nachweis von TLR5 in Proben von Human und Maus. Er wurde validiert für WB, IHC (p) und IF.

Kurzübersicht für TLR5 Antikörper (C-Term) (ABIN302879)

Target: TLR5 (Toll-Like Receptor 5 (TLR5))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-TLR5 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts with a peptide corresponding to 15 amino acids near the carboxy terminus of TLR5.

Kreuzreaktivität (Details): Species reactivity (expected):Human.
Species reactivity (tested):Mouse.

Aufreinigung: Affinity Chromatography.

Immunogen: Synthetic peptide corresponding to 15 amino acids near the carboxy terminus of TLR5.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1-2 μg/mL. Immunohistochemistry: 5 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu TLR5

Target: TLR5 (Toll-Like Receptor 5 (TLR5))

Andere Bezeichnung: TLR5

Hintergrund: The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens.Synonyms: TIL3, Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3

Gen-ID: 7100

NCBI Accession: NP_003259

UniProt: O60602

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades