c-MYC Antikörper (AA 408-439)

Produktnummer ABIN3026176

Der Maus Monoklonal anti-c-MYC Antikörper (Klon MYC699) (ABIN3026176) detektiert spezifisch c-MYC in IF, ELISA und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für c-MYC Antikörper (AA 408-439) (ABIN3026176)

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser c-MYC Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), ELISA, Flow Cytometry (FACS)

Güteklasse: Carrier-free

Klon: MYC699

Produktdetails anti-c-MYC Antikörper

Bindungsspezifität: AA 408-439

Verwendungszweck: c-Myc Antibody (azide and preservative free)

Sequenz: AEEQKLISEE DLLRKRREQL KHKLEQLRNS CA

Keine Kreuzreaktivität: Maus

Aufreinigung: Protein G affinity chromatography

Immunogen: Amino acids 408-439 (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA) from the human protein were used as the immunogen for this c-Myc antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: The optimal dilution of the c-Myc antibody for each application should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the c-Myc antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu c-MYC

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Andere Bezeichnung: c-Myc

Hintergrund: The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.

UniProt: P01106

Pathways: p53 Signalweg, Zellzyklus, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effekt