c-MYC Antikörper (AA 257-439)

Produktnummer ABIN3043598

Es sind 13+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-c-MYC Antikörper wird verwendet zum Nachweis von c-MYC in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IF und ICC.

Kurzübersicht für c-MYC Antikörper (AA 257-439) (ABIN3043598)

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser c-MYC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-c-MYC Antikörper

Bindungsspezifität: AA 257-439

Verwendungszweck: Anti-c-Myc Antibody

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human c-Myc shares 91% amino acid (aa) sequences identity with both mouse,rat c-Myc.

Produktmerkmale: Anti-c-Myc Antibody. Tested in IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human c-Myc recombinant protein (Position: E257-A439). Human c-Myc shares 91% amino acid (aa) sequences identity with both mouse and rat c-Myc.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-c-MYC Antikörper (ABIN3043598)

Zhang, Chang, Zhao, Gao, Wang, Li, Zhang, Zhang, Xu: "The novel protein C9orf116 promotes rat liver cell line BRL-3A proliferation." in: PLoS ONE, Vol. 12, Issue 7, pp. e0180607, (2017) (PubMed).

Zhang, Chang, Li, Zhang, Xu: "The novel protein C3orf43 accelerates hepatocyte proliferation." in: Cellular & molecular biology letters, Vol. 22, pp. 21, (2017) (PubMed).

Hao, Wen, Li, Wang, Ni, Wang, Wang, Sun, Fan, Mao: "LiCl inhibits PRRSV infection by enhancing Wnt/?-catenin pathway and suppressing inflammatory responses." in: Antiviral research, Vol. 117, pp. 99-109, (2015) (PubMed).

Zhao, Li, Gao, Wang, Yan, Zhan, Liu, Mao, Chen, Wang et al.: "Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase kinase 3? (GSK-3?) ..." in: European journal of medicinal chemistry, Vol. 86, pp. 165-74, (2014) (PubMed).

Wang, Gu, Wan, Zhu, Qiu, Weng, Yu, He: "Litopenaeus vannamei sterile-alpha and armadillo motif containing protein (LvSARM) is involved in regulation of Penaeidins and antilipopolysaccharide factors." in: PLoS ONE, Vol. 8, Issue 2, pp. e52088, (2013) (PubMed).

Li, Tian, Wang, Yao, Zhang, Lu, Sun, Gao, Xiao, Liu: "Down-regulation of miR-129-5p inhibits growth and induces apoptosis in laryngeal squamous cell carcinoma by targeting APC." in: PLoS ONE, Vol. 8, Issue 10, pp. e77829, (2013) (PubMed).

Yuan, Zhang, Cai, Ding, Wang, Chen, Wang, Yan, Lu: "Leptin induces cell proliferation and reduces cell apoptosis by activating c-myc in cervical cancer." in: Oncology reports, Vol. 29, Issue 6, pp. 2291-6, (2013) (PubMed).

Zhang, Lu, Yang, Li, Sun, Tao, Liu, Zhang, Ma: "HILI inhibits TGF-? signaling by interacting with Hsp90 and promoting T?R degradation." in: PLoS ONE, Vol. 7, Issue 7, pp. e41973, (2012) (PubMed).

Yang, Gu, Zheng, Li, Lian, Miao, Jiang, Wei: "RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11865-74, (2011) (PubMed).

Qin, Hua, Shuang, Wang, Cui: "Effects of matrine on HepG2 cell proliferation and expression of tumor relevant proteins in vitro." in: Pharmaceutical biology, Vol. 48, Issue 3, pp. 275-81, (2010) (PubMed).

Wang, Huo, Li, Fu, Xue, Yang, Wen, Ding, Duan: "Osteogenic role of endosomal chloride channels in MC3T3-E1 cells." in: Molecular and cellular biochemistry, Vol. 342, Issue 1-2, pp. 191-9, (2010) (PubMed).

Liu, Liu, Bai, Li, Yang: "Molecular cloning, expression and subcellular distribution of an alternative splice variant of the porcine Sirt2 gene." in: Molecular biology reports, Vol. 37, Issue 3, pp. 1671-6, (2010) (PubMed).

Long, Sun, Hu, Liang, Wang, Zhang, Cao, Zhen, Cui, Liu: "Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer." in: Oncology reports, Vol. 22, Issue 5, pp. 1189-95, (2009) (PubMed).

Details zu c-MYC

Target: c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))

Andere Bezeichnung: MYC

Hintergrund:

Background: C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. C-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol (2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.

Gene Full Name: MYC proto-oncogene, bHLH transcription factor

Sequence Similarities: Contains 1 bHLH (basic helix-loop-helix) domain.

Molekulargewicht: 60-65 kDa

Gen-ID: 4609

UniProt: P01106

Pathways: p53 Signalweg, Zellzyklus, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effekt