ZAP70 Antikörper (pTyr319)

Produktnummer ABIN3023646

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ZAP70 in WB, IHC, IF und IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ZAP70 Antikörper (pTyr319) (ABIN3023646)

Target: ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZAP70 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-ZAP70 Antikörper

Bindungsspezifität: pTyr319

Sequenz: SPYSD

Kreuzreaktivität: Human

Produktmerkmale: Phosphorylated Antibodies

Immunogen: A synthetic phosphorylated peptide around Y319 of human ZAP70 (NP_001070.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ZAP70

Target: ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

Andere Bezeichnung: ZAP70

Hintergrund: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.,ZAP70,ADMIO2,IMD48,SRK,STCD,STD,TZK,ZAP-70,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Hippo Signaling Pathway,Immunology & Inflammation,T Cell Receptor Signaling Pathway,Protein phosphorylation,ZAP70

Molekulargewicht: 35 kDa/55 kDa/69 kDa

Gen-ID: 7535

UniProt: P43403

Pathways: T-Zell Rezeptor Signalweg, Ubiquitin Proteasome Pathway