Caspase 3 Antikörper (AA 55-160)

Produktnummer ABIN3023067

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Caspase 3 in WB, IHC und IF. Er zeigt eine Reaktivität gegenüber Human und wurde in 17+ Publikationen erwähnt.

Kurzübersicht für Caspase 3 Antikörper (AA 55-160) (ABIN3023067)

Target: Caspase 3 (CASP3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caspase 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Caspase 3 Antikörper

Bindungsspezifität: AA 55-160

Sequenz: FHKSTGMTSR SGTDVDAANL RETFRNLKYE VRNKNDLTRE EIVELMRDVS KEDHSKRSSF VCVLLSHGEE GIIFGTNGPV DLKKITNFFR GDRCRSLTGK PKLFII

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 55-160 of human Caspase-3 (NP_004337.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-Caspase 3 Antikörper (ABIN3023067)

Zhao, Liu, Lin, Huang, He, Zhang, Dong, Wen, Rao, Liao, Shi: "The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1." in: Molecular cancer, Vol. 17, Issue 1, pp. 69, (2019) (PubMed).

Huang, Cui, Chen, Yang, Lian, Liu, Su, Liu, Wang, Hu, Ouyang, Li, Lu: "NVP-BEZ235 synergizes cisplatin sensitivity in osteosarcoma." in: Oncotarget, Vol. 9, Issue 12, pp. 10483-10496, (2018) (PubMed).

Zhang, Zhang, Deng, Zhang, Liu, Xin, Li, Xu: "Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice." in: Life sciences, Vol. 192, pp. 46-54, (2018) (PubMed).

Xueting, Rehman, Mehmood, Huang, Tian, Wu, Zhou: "Ameliorative effects of nano-elemental selenium against hexavalent chromium-induced apoptosis in broiler liver." in: Environmental science and pollution research international, Vol. 25, Issue 16, pp. 15609-15615, (2018) (PubMed).

Li, Lu, Bai, Xiao, Guo, Dong: "Ginsenoside Rg3 Suppresses Proliferation and Induces Apoptosis in Human Osteosarcoma." in: BioMed research international, Vol. 2018, pp. 4306579, (2018) (PubMed).

Yan, Du, Li, Chen, Yan, Chen, Hu, Chang: "CO suppresses prostate cancer cell growth by directly targeting LKB1/AMPK/mTOR pathway in vitro and in vivo." in: Urologic oncology, Vol. 36, Issue 6, pp. 312.e1-312.e8, (2018) (PubMed).

Jiang, Liu, Ni, Wei, Li, Xing, Kong, Li: "Primary study on the toxic mechanism of vanadyl trehalose in Kunming mice." in: Regulatory toxicology and pharmacology : RTP, Vol. 94, pp. 1-7, (2018) (PubMed).

Ding, Wen: "Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis." in: Journal of natural medicines, Vol. 72, Issue 4, pp. 857-866, (2018) (PubMed).

Knowlton, Fernández de Castro, Ashbrook, Gestaut, Zamora, Bauer, Forrest, Frydman, Risco, Dermody: "The TRiC chaperonin controls reovirus replication through outer-capsid folding." in: Nature microbiology, Vol. 3, Issue 4, pp. 481-493, (2018) (PubMed).

Wu, Liu, Gong, Liu, Zhang, Leng, Zhang, Li: "VCPA, a novel synthetic derivative of α-tocopheryl succinate, sensitizes human gastric cancer to doxorubicin-induced apoptosis via ROS-dependent mitochondrial dysfunction." in: Cancer letters, Vol. 393, pp. 22-32, (2017) (PubMed).

Xu, Tang, Bei, Ding, Che, Yao, Wang, Lv, Xiao: "miR-19b attenuates H2O2-induced apoptosis in rat H9C2 cardiomyocytes via targeting PTEN." in: Oncotarget, Vol. 7, Issue 10, pp. 10870-8, (2017) (PubMed).

Liu, Liu, He, Zhang, Liu, Wang, Qiu, Xu, Xiang, Lv: "Differential gene and lncRNA expression in the lower thoracic spinal cord following ischemia/reperfusion-induced acute kidney injury in rats." in: Oncotarget, Vol. 8, Issue 32, pp. 53465-53481, (2017) (PubMed).

Gou, Zhao, Fan, Yuan, Liao, He, Xu, Chen: "Autophagy induces apoptosis and death of T lymphocytes in the spleen of pigs infected with CSFV." in: Scientific reports, Vol. 7, Issue 1, pp. 13577, (2017) (PubMed).

Jiang, Liao, He, Xin, Tu, Kong, Cui, Wang, Quan, Li, Zhang, Wang: "FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization." in: Scientific reports, Vol. 5, pp. 13735, (2016) (PubMed).

Wang, Zhu, Li, Yang, Xiao, Kang, Li, Zhao, Zeng, Li, Zhang, He, Ying et al.: "Crude Saponins of Panax notoginseng Have Neuroprotective Effects To Inhibit Palmitate-Triggered Endoplasmic Reticulum Stress-Associated Apoptosis and Loss of Postsynaptic Proteins in Staurosporine ..." in: Journal of agricultural and food chemistry, Vol. 64, Issue 7, pp. 1528-39, (2016) (PubMed).

Luo, Fu, Xu, Su, Ren, Li, Zhu, Zhao, Dai, Cao, Wang, Qin, Jiang, Li, Wu, Feng, Chen, Wang: "PSMD10/Gankyrin Induces Autophagy to Promote Tumor Progression through Cytoplasmic Interaction with ATG7 and Nuclear Transactivation of ATG7 Expression." in: Autophagy, (2015) (PubMed).

Kim, Kim, Yoon, Lee, Kuh: "Indirect modulation of sensitivity to 5-fluorouracil by microRNA-96 in human colorectal cancer cells." in: Archives of pharmacal research, Vol. 38, Issue 2, pp. 239-48, (2015) (PubMed).

Details zu Caspase 3

Target: Caspase 3 (CASP3)

Andere Bezeichnung: CASP3

Hintergrund: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.,CPP32,CPP32B,SCA-1,Active Caspase 3,CASP3,active Caspase-3,Caspase 3,Caspase-3 p12,caspase-3,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Caspases,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Death Receptor Signaling Pathway,Hippo Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,CASP3

Molekulargewicht: 31 kDa

Gen-ID: 836

UniProt: P42574

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation