Dynactin 1 Antikörper (AA 945-1139)

Produktnummer ABIN3022542

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Dynactin 1 in WB und IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Dynactin 1 Antikörper (AA 945-1139) (ABIN3022542)

Target: Dynactin 1 (DCTN1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Dynactin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-Dynactin 1 Antikörper

Bindungsspezifität: AA 945-1139

Sequenz: PGLVKDSPLL LQQISAMRLH ISQLQHENSI LKGAQMKASL ASLPPLHVAK LSHEGPGSEL PAGALYRKTS QLLETLNQLS THTHVVDITR TSPAAKSPSA QLMEQVAQLK SLSDTVEKLK DEVLKETVSQ RPGATVPTDF ATFPSSAFLR AKEEQQDDTV YMGKVTFSCA AGFGQRHRLV LTQEQLHQLH SRLIS

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 945-1139 of human DCTN1 (NP_001128513.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IP,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Dynactin 1

Target: Dynactin 1 (DCTN1)

Andere Bezeichnung: DCTN1

Hintergrund: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).,DCTN1,DAP-150,DP-150,P135,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cytoskeleton,Motor Proteins,Neuroscience,Neurodegenerative Diseases,DCTN1

Molekulargewicht: 126 kDa/127 kDa/136 kDa/138 kDa/140 kDa/141 kDa

Gen-ID: 1639

UniProt: Q14203

Pathways: M Phase, ER-Nucleus Signaling