Dynactin 1 Antikörper

Produktnummer ABIN7259741

Produktdetails anti-Dynactin 1 Antikörper

Target: Dynactin 1 (DCTN1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Dynactin 1 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein of human DCTN1 (NP_001128513.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF 1:20-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Dynactin 1

Target: Dynactin 1 (DCTN1)

Andere Bezeichnung: DCTN1 (DCTN1 Produkte)

Synonyme: DAP-150 antikoerper, DP-150 antikoerper, P135 antikoerper, Chip150 antikoerper, DCTN1 antikoerper, DKFZp469C1813 antikoerper, AL022633 antikoerper, Glued antikoerper, p150 antikoerper, p150 antikoerper, CG9206 antikoerper, DYNA_DROME antikoerper, Dmel\\CG9206 antikoerper, FCP-D antikoerper, Glu antikoerper, P150 antikoerper, P150[Glued] antikoerper, p150/Glued antikoerper, p150/glued antikoerper, p150[Glued] antikoerper, p150[glued] antikoerper, t1 antikoerper, Dynactin-1 antikoerper, glued antikoerper, dynactin subunit 1 antikoerper, dynactin 1 antikoerper, Dynactin 1, p150 subunit antikoerper, dynactin subunit 1 L homeolog antikoerper, DCTN1 antikoerper, Dctn1 antikoerper, DCTN1-p150 antikoerper, dctn1.L antikoerper

Hintergrund: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

Gen-ID: 1639

UniProt: Q14203

Pathways: M Phase, ER-Nucleus Signaling