SHP1 Antikörper (AA 100-400)

Produktnummer ABIN3021975

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SHP1 in WB und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SHP1 Antikörper (AA 100-400) (ABIN3021975)

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SHP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-SHP1 Antikörper

Bindungsspezifität: AA 100-400

Sequenz: LNCSDPTSER WYHGHMSGGQ AETLLQAKGE PWTFLVRESL SQPGDFVLSV LSDQPKAGPG SPLRVTHIKV MCEGGRYTVG GLETFDSLTD LVEHFKKTGI EEASGAFVYL RQPYYATRVN AADIENRVLE LNKKQESEDT AKAGFWEEFE SLQKQEVKNL HQRLEGQRPE NKGKNRYKNI LPFDHSRVIL QGRDSNIPGS DYINANYIKN QLLGPDENAK TYIASQGCLE ATVNDFWQMA WQENSRVIVM TTREVEKGRN KCVPYWPEVG MQRAYGPYSV TNCGEHDTTE YKLRTLQVSP L

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human SHP1 (NP_002822.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SHP1

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Andere Bezeichnung: PTPN6

Hintergrund: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.,HCP,HCPH,HPTP1C,PTP-1C,SH-PTP1,SHP-1,SHP-1L,SHP1,CTCN6,PTPN6,Cancer,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Immunology & Inflammation,B Cell Receptor Signaling Pathway,IL-6 Receptor Signaling Pathway,PTPN6

Molekulargewicht: 63 kDa/67 kDa/70 kDa

Gen-ID: 5777

UniProt: P29350

Pathways: JAK-STAT Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling